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LPA — MMP2
Text-mined interactions from Literome
Fishman et al., Cancer Res 2001
(Neoplasm Invasiveness...) :
In the current study, the
effect of
LPA on
MMP expression and invasive activity was investigated
Matsumoto et al., Jpn J Cancer Res 2001
(Bone Neoplasms...) :
High
LPA suppressed the activation of
MMP2 through down-regulation of MT1-MMP and TIMP2
Wu et al., Endocrinology 2005
:
In our present study, we examined the
effects of
LPA and S1P on
MMP-2 expression in human endothelial cells ... We showed that
LPA and S1P
enhanced MMP-2 expression in mRNA, protein levels, and also enzymatic activity of cells of the EAhy926 human endothelial cell line
Zhao et al., J Biol Chem 2006
:
Overexpression of dominant negative PKCdelta or pretreatment with a PKCdelta inhibitor ( rottlerin ) or Src kinase family inhibitor ( PP2 ) partially blocked
LPA induced
MMP activation, proHB-EGF shedding, and EGFR tyrosine phosphorylation ... Down-regulation of Lyn kinase, but not Src kinase, by specific small interfering RNA mitigated
LPA induced
MMP activation, proHB-EGF shedding, and EGFR phosphorylation
Do et al., Mol Cancer Res 2007
(Ovarian Neoplasms) :
Because the underlying mechanism governing LPA regulation of matrix metalloproteinase-2 (MMP-2) activation remains undefined, we investigated the relationship between
LPA induced changes in actin microfilament organization and
MMP-2 enzymatic activity ... Inhibition of Rho-kinase/ROCK enhanced both
LPA stimulated loss of stress fibers and
pro-MMP-2 activation ... In contrast, expression of the constitutively active RhoA ( G14V ) mutant diminished
LPA induced
pro-MMP-2 activation ...
LPA had no effects on membrane type 1-MMP or tissue inhibitor of metalloproteinase-2 expression, but
up-regulated MMP-2 levels, contributing to the induction of MMP-2 activation
Wang et al., Gynecol Oncol 2011
(Neoplasm Invasiveness...) :
Furthermore,
MMP-1 and PAR1 were both significantly
induced by
LPA ( 20 µM ), and siRNA silencing of MMP-1 and PAR1 both significantly reduced LPA 's invasion promoting effect in DOV13 cells ( p < 0.05 )
Dutta et al., Gynecol Oncol 2011
(Neoplasm Invasiveness...) :
Additionally, NF-?B inhibition also decreased
LPA induced
MMP-2 secretion and MMP-1 expression ( p < 0.05 )
Komachi et al., Cancer Sci 2012
(Ascites...) :
Ki16198 inhibited LPA induced migration and invasion in several pancreatic cancer cells in vitro, which was associated with the inhibition of
LPA induced
MMP production
Lou et al., J Int Med Res 2013
(Carcinoma, Hepatocellular...) :
This study investigated the
effects of
LPA on HCC cell invasion and induction of
matrix metalloproteinase (MMP) -2 and -9 ... Real-time RT-qPCR showed that
LPA increased MMP9, but not
MMP2 , expression in HCC cells