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PLD1 — VEGFA

Text-mined interactions from Literome

Cho et al., Am J Physiol Heart Circ Physiol 2004 : Moreover, VEGF increased PLD activity in a time- and dose dependent manner in HUVECs, whereas a ligand specific for VEGFR-1 placental growth factor did not change PLD activity ... Pharmacological analyses using several inhibitors indicated that PKC-delta regulates the VEGF induced activation of PLD/ERK
Zhang et al., Blood 2010 (Retinal Neovascularization) : Furthermore, siRNA mediated down-regulation of VEGF inhibited hypoxia induced Src-PLD1-PKCgamma activation and neovascularization
Chen et al., Science signaling 2012 (Breast Neoplasms...) : PLD1 deficiency suppressed the activation of Akt and mitogen activated protein kinase signaling pathways by vascular endothelial growth factor in vascular endothelial cells, resulting in decreased integrin dependent cell adhesion to, and migration on, extracellular matrices, as well as reduced tumor angiogenesis in a xenograft model
Singh et al., Blood 2013 (Anoxia...) : To understand the mechanisms of Src-PLD1-PKC?-cPLA activation by vascular endothelial growth factor A ( VEGFA ), we studied the role of Kdr and Flt1 ... Depletion of Kdr attenuated VEGFA induced Src-PLD1-PKC?-cPLA activation ... Regardless of its phosphorylation state, downregulation of Flt1 also inhibited VEGFA induced Src-PLD1-PKC?-cPLA activation , but only modestly ... Furthermore, depletion of VEGFA or VEGFB attenuated hypoxia induced Src-PLD1-PKC?-cPLA activation and retinal neovascularization ... These findings suggest that although VEGFA, through Kdr and Flt1, appears to be the major modulator of Src-PLD1-PKC?-cPLA signaling in HRMVECs, facilitating their angiogenic events in vitro, both VEGFA and VEGFB mediate hypoxia induced Src-PLD1-PKC?-cPLA activation and retinal neovascularization via activation of Kdr and Flt1, respectively