Gene interactions and pathways from curated databases and text-mining

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ACO2 — PPARA

Text-mined interactions from Literome

Lazennec et al., Mol Endocrinol 2000 : Moreover, comparing PPAR alpha knockout ( KO ) with PPAR alpha WT mice, we show that the expression of the acyl CoA oxidase ( ACO ) gene can be regulated by PKA activated PPAR alpha in liver
Bretillon et al., Lipids 2003 (Body Weight) : In the present work, CFAM ( 0.5 % of the diet ) were administered for 3 wk to wild-type and PPARalpha-null mice of both genders to elucidate the role of PPARalpha in mediating the effects of CFAM on the activity of acyl-CoA oxidase ( ACO ) and omega-laurate hydroxylase ( CYP4A ), the regulation of which is known to be dependent on the PPARalpha
Ahmed et al., Circ Res 2006 : Moreover, HDL stimulation induced expression of the canonical PPARalpha-target gene acyl-CoA-oxidase ( ACO ) in a PPARalpha dependent manner in ECs
Krey et al., Mol Endocrinol 1995 : We identified several functional cis acting elements present in the promoter of the ACO gene and established that PPAR dependent as well as PPAR independent mechanisms can activate the ACO promoter in these cells
Belury et al., Toxicol Appl Pharmacol 1998 : The involvement of PPAR in the peroxisome proliferator mediated induction of fatty acid metabolizing genes such as acyl-CoA oxidase ( ACO ) , fatty acid binding protein (FABP), and cytochrome P450IVA1 ( CYP4A1 ) has been clearly demonstrated