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BCR — CD72
Text-mined interactions from Literome
Adachi et al., J Immunol 2000
(Calcium Signaling...) :
These results indicate that
CD72 negatively
regulates BCR signaling
Adachi et al., J Biol Chem 2001
:
Here we demonstrate that, in the BCR expressing myeloma line J558L mu 3,
CD72 expression
reduces the
BCR ligation induced phosphorylation of the BCR component Ig alpha/Ig beta and its cytoplasmic effectors Syk and SLP-65 ... Taken together, BCR induced SHP-1 activation is likely to require inhibitory co-receptors such as CD72, and SHP-1 appears to mediate the negative regulatory
effect of
CD72 on
BCR signaling by dephosphorylating Ig alpha/Ig beta and its downstream signaling molecules Syk and SLP-65
Li et al., Arthritis Rheum 2008
(Autoimmune Diseases) :
Biochemical analyses indicated that in anergic B cells,
CD72 dominantly
down-regulated BCR signaling to limit the antigen induced elevation in [ Ca2+ ] i and the activation of NFATc1, NF-kappaB, MAPK, and Akt ... Mechanistically, CD72 was associated with, and regulated, the molecular adaptor Cbl-b in anergic B cells, suggesting that Cbl-b may play a role in mediating the negative
effects of
CD72 on
BCR signaling
Xu et al., J Immunol 2013
(Autoimmune Diseases...) :
We further demonstrated that Cd72(c) is a hypofunctional allele in
BCR signal inhibition and that
CD72 deficiency
induces severe autoimmune disease in the presence of Fas ( lpr )
Adachi et al., J Immunol 1998
:
Moreover, cross linking of
B cell Ag receptor (BCR) enhances both tyrosine phosphorylation of CD72 and association of
CD72 with SHP-1 in B cell line WEHI-231