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FAS — TNFSF11

Text-mined interactions from Literome

Wu et al., J Bone Miner Res 2005 (Bone Resorption) : RANKL regulates Fas expression and Fas mediated apoptosis in osteoclasts ... Western blotting, semiquantitative RT-PCR, flow cytometry, nuclear staining, and a fluorescent caspase-3 activity assay were used to assess the effect of RANKL on Fas expression and Fas mediated apoptosis ... The involvement of NF-kappaB in the regulation of Fas by RANKL was analyzed by luciferase assay and EMSA ... The regulation of Fas expression by RANKL is biphasic ... During the early stage of osteoclastogenesis ( 1 day ) when Fas is expressed at a very low level, RANKL upregulates Fas promoter activity by 2.4 +/- 0.1-fold in a concentration dependent manner and increases Fas mRNA and protein ... In osteoclast precursors, the induction of Fas promoter activity by RANKL was dramatically reduced when NF-kappaB binding sites on the Fas promoter were mutated ... RANKL upregulates Fas expression in osteoclast progenitors through NF-kappaB, making osteoclasts targets of Fas stimulated apoptosis ... In differentiated mature osteoclasts, RANKL reduces the levels of Fas expression and Fas mediated apoptosis, acting as a survival factor
Assohou-Luty et al., J Mol Med (Berl) 2006 : Fusion proteins of RANK and CD95L ( RANKed CD95Led ) and CD40 and tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) ( CD40ed TRAILed ), with domain architectures similar to CD40ed Cd95Led, displayed RANKL dependent CD95 and CD40L dependent TRAILR2 activation, respectively, indicating the principle feasibility of this fusion protein design
Izawa et al., Blood 2007 : By contrast, Fas expression of BMDCs from normal C57BL/6 and MRL ( +/+ ) mice was increased by RANKL stimulation, and an enhanced DC apoptosis was found when stimulated with both RANKL and anti-Fas mAb, which was associated with activation of caspase-3 and caspase-9