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EPHB2 — LEP

Text-mined interactions from Literome

Takekoshi et al., Endocrinology 2001 : Nicardipine and omega-conotoxin GVIA, each at 1 microM, were effective at inhibiting leptin induced TH enzyme activity, TH mRNA accumulation, PKC activity, and ERK activity ... The present study also showed that H89 ( a PKA inhibitor ) moderately, but significantly, inhibited leptin induced ERK and TH mRNA
O'Rourke et al., Biochem J 2002 : Leptin induced ERK activation in J774.2 cells shows a biphasic pattern, with an initial reduction in ERK phosphorylation for up to 10 min following leptin stimulation, while at later time points phosphorylation of ERK was increased above basal levels
Kim et al., J Biol Chem 2003 : Leptin activated ERK , but not p38 and JNK, and up-regulated cPLA2 activity ; the latter was abolished by pre-treatment of cells with the MEK inhibitor ( PD98059 or U0126 ) or cPLA2 inhibitor ( AACOCF3 )
Saxena et al., FASEB J 2004 : Further, the PI-3 kinase inhibitor LY294002 and MAPK inhibitor PD98059 were found to significantly reduce leptin induced HSC proliferation, thereby indicating that leptin induced HSC proliferation is Akt- and Erk dependent
Pai et al., Biochem Biophys Res Commun 2005 (Stomach Neoplasms) : Inhibition of SHP2 expression with siRNA but not SHP2 phosphatase activity abolished leptin induced ERK2 activation ... While JAK inhibition with AG490 significantly reduced leptin induced ERK2 , STAT3 phosphorylation, and cell proliferation, SHP2 inhibition only partially reduced cancer cell proliferation
Li et al., Diabetes 2005 : Treatment of HASMCs with metformin decreased leptin induced ROS production and activation of PKC, ERK1/2 , and NF-kappaB
Lee et al., Int J Obes Relat Metab Disord 2005 (Hyperplasia...) : We also confirm that leptin activates both PI 3-kinase and ERK1/2 in these cells
Solberg et al., J Cell Biochem 2005 : A functional leptin receptor was demonstrated by an acute leptin induced 1.5-fold increase in ERK activity ( P = 0.029 )
Zhao et al., Cell Immunol 2005 (MAP Kinase Signaling System) : Although gAd partially increased cAMP concentration and PKA activity, it directly reduced leptin induced ERK1/2 and p38 MAPK phosphorylation thus inhibiting TNF-alpha production
Sharma et al., Endocr Relat Cancer 2006 (Endometrial Neoplasms...) : Moreover, leptin induced phosphorylation of ERK2 and AKT was dependent on JAK/STAT activation
Bełtowski et al., Peptides 2006 : H2O2 and Src dependent transactivation of the EGF receptor mediates the stimulatory effect of leptin on renal ERK and Na+, K+-ATPase ... The effect of leptin on ERK and Na ( + ), K ( + ) -ATPase was abolished by catalase, specific inhibitors of epidermal growth factor (EGF) receptor, AG1478 and PD158780, as well as by ERK inhibitor, PD98059, and was mimicked by both exogenous H ( 2 ) O ( 2 ) and EGF
Cui et al., FASEB J 2006 : Leptin signaling in neurotensin neurons involves STAT, MAP kinases ERK1/2 , and p38 through c-Fos and ATF1 ... Leptin induced phosphorylation of STAT3 and MAPK ERK1/2 , but not the downstream effector of PI3K, Akt, and also induced c-Fos protein
Hoda et al., Br J Surg 2007 (Colonic Neoplasms...) : Leptin also caused ERK1/2 and Akt phosphorylation
Saxena et al., Cancer Res 2007 (Carcinoma, Hepatocellular...) : Leptin induced phosphorylation of ERK and AKT was dependent on Janus activated kinase ( JAK ) /STAT activation
Sirotkin et al., Comp Biochem Physiol A Mol Integr Physiol 2007 : Finally, leptin inhibited expression of MAPK/ERK1,2 and CDK/p34 and stimulated expression of PKA
Beales et al., Mol Cell Endocrinol 2007 (Adenocarcinoma...) : Leptin synergistically enhanced acid stimulated EGFR and ERK phosphorylation but did not further increase JNK or p38 MAP kinase phosphorylation
Ben-Eliezer et al., Endocrine 2007 : It was found that leptin increased phosphorylation of ERK1/2 , p38, and STAT3 in a time- and dose dependent manner ... Moreover, leptin induced the translocation of ERK1/2 into the nucleus, as well as c-fos expression, indicating full activation of this cascade
Wójcicka et al., Life Sci 2008 (Disease Models, Animal...) : Leptin increased ERK phosphorylation level in renal and aortic tissues more markedly after 4 than after 8 days of treatment ... NADPH oxidase inhibitor, apocynin, prevented leptin 's effect on BP, ERK , Na ( + ), K ( + ) -ATPase/Na ( + ) excretion and NO formation at all time points
Tipsmark et al., J Endocrinol 2008 : We therefore tested whether ERK1/2 might be involved in the leptin PRL response and found that the ERK inhibitor, PD98059, hindered leptin induced PRL release
Garza et al., J Biol Chem 2008 : Analysis of signal transduction pathways revealed that leptin stimulated phosphorylation of Akt and STAT3 but not ERK1/2
Jiang et al., J Biol Chem 2008 : Overexpression of c-Src or Fyn, two Src family members, promoted STAT3 phosphorylation, whereas inhibition of the endogenous Src family members by either pharmacological inhibitors or dominant negative Src ( K298M ) decreased the ability of leptin to stimulate the phosphorylation of STAT3 and ERK1/2
Benomar et al., Endocrinology 2009 : Leptin pretreatment completely abolished leptin dependent STAT-3 and ERK 1/2 phosphorylations without affecting CNTF action
Rahmouni et al., Diabetes 2009 (Body Weight) : Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin ... Biochemical, pharmacological, and physiological approaches were combined to characterize leptin activation of ERK in the hypothalamus in rats ... Leptin activates ERK1/2 in a receptor mediated manner that involves JAK2 ... Leptin induced ERK1/2 activation was restricted to the hypothalamic arcuate nucleus
Woolson et al., Cell Signal 2009 : Here we demonstrate that elevation of cyclic AMP ( cAMP ) levels in human umbilical vein endothelial cells ( HUVECs ) specifically attenuates ERK1,2 activation in response to either leptin or a soluble interleukin IL-6 receptor-alpha/IL-6 ( sIL-6R alpha/IL-6 ) trans signalling complex but not protein kinase C activator phorbol 12-myristate 13-acetate
Lin et al., Reproductive biology and endocrinology : RB&E 2009 : Leptin induces the activation of ERK1/2, p38 and JNK but only the ERK1/2 ( PD98059 ) and p38 ( SB203580 ) inhibitors attenuate the leptin induced inhibition of cAMP stimulated StAR protein expression and progesterone production
Kim et al., Oncol Rep 2010 (Leukemia, Myeloid, Acute) : The blocking of STAT3 phosphorylation with the specific inhibitor, AG490, significantly reduced leptin induced ERK1/2 phosphorylation and cellular proliferation, whereas the blocking of ERK1/2 activation by the specific ERK1/2 inhibitor, PD98059, did not affect the STAT3 phosphorylation or leptin induced proliferation in HEL cells ... Furthermore, knockdown of leptin receptor ( OB-R ) expression with stealth RNA interference ( RNAi ) reduced the leptin induced proliferation of HEL cells and also significantly attenuated leptin induced STAT3 and ERK1/2 activation
Hoda et al., Aktuelle Urol 2010 (Adenocarcinoma...) : Leptin also caused dose dependent ERK1 / 2 phosphorylation in both androgen-resistant cell lines
Naviglio et al., J Cell Physiol 2010 (Breast Neoplasms) : Interestingly, intracellular cAMP elevation upon forskolin pretreatment completely abrogated both ERK1/2 and STAT3 phosphorylation in response to leptin and was accompanied by a consistent CREB phosphorylation ... Importantly, pretreatment with the PKA inhibitor KT-5720 blocked the forskolin induced CREB phosphorylation and prevented both the inhibition by forskolin of leptin induced ERK1/2 and STAT3 phosphorylation and the PKA subunits down-regulation induced by the combination of leptin and forskolin
Singh et al., Atherosclerosis 2011 (Atherosclerosis) : The effect of increased caveolin-1 expression on leptin dependent activation of ERK1/2 and eNOS was determined by Western blot analysis
Vallet et al., Leukemia 2011 (Multiple Myeloma...) : Our results suggest that CCL3 effects on OBs are mediated by ERK activation and subsequent downregulation of the osteogenic transcription factor osterix
Liu et al., J Huazhong Univ Sci Technolog Med Sci 2011 (Adenocarcinoma...) : The results showed that leptin induced the phosphorylation of STAT3 and the activation of ERK1/2 in a time- and dose dependent manner in the Ishikawa endometrial cancer cells
Deng et al., J Trauma Acute Care Surg 2012 (MAP Kinase Signaling System...) : We further demonstrated that leptin markedly activated ERK1/2 in the intestines and activated ERK1/2 and cPLA2 in the cells
He et al., Mol Cell Biol 2012 (Body Weight...) : Biochemical analyses showed a physical association of Shp2 with estrogen receptor alpha, which is necessary for the synergistic and persistent activation of Erk by leptin and estrogen
Hoda et al., Journal of oncology 2012 : Further, leptin caused dose dependent ERK1/2 phosphorylation in both androgen-resistant cell lines, and pretreatment of these cells with PD98059 inhibited these responses
Moon et al., Diabetologia 2013 : Amylin induced downregulation of hippocampal neurogenesis is attenuated by leptin in a STAT3/AMPK/ERK dependent manner in mice
Li et al., PloS one 2012 : Mechanistically, leptin induced the phosphorylation of STAT3, Akt and ERK1/2 accompanied by the upregulation of cyclin D1
Taliaferro-Smith et al., Neoplasia (New York, N.Y.) 2013 (Breast Neoplasms...) : Pretreatment of breast cancer cells with adiponectin protects against leptin induced activation of ERK and Akt
Spina et al., BioResearch open access 2012 : Recently, we demonstrated that in MDA-MB-231 breast cancer cells, intracellular cAMP elevation completely abrogates both ERK1/2 and STAT3 phosphorylation in response to leptin