Gene interactions and pathways from curated databases and text-mining

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IL6 — TNC

Text-mined interactions from Literome

Kuriyama et al., Hepatology 2011 (Reperfusion Injury) : The lack of Tnc expression resulted in impaired leukocyte recruitment and decreased expressions of interleukin (IL)-1ß, IL-6 , and CXCL2 after liver reperfusion
Maqbool et al., Matrix Biol 2013 : ECM-regulatory matricellular proteins are synthesized by several myocardial cell types including CF. We investigated the effects of pro-inflammatory cytokines on matricellular protein expression in cultured human CF. cDNA array analysis of matricellular proteins revealed that interleukin-1a ( IL-1a, 10ng/ml, 6h ) down-regulated connective tissue growth factor ( CTGF/CCN2 ) mRNA by 80 % and up-regulated tenascin-C (TNC) mRNA levels by 10-fold in human CF, without affecting expression of thrombospondins 1-3, osteonectin or osteopontin