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CRH — TNF

Text-mined interactions from Literome

De Souza et al., Inflamm Res 2002 : Indomethacin or dipyrone reduced LPS, IL-1beta, IL-6 or TNF-alpha induced fever and CRH release from rat hypothalamus
Agelaki et al., Infect Immun 2002 (Shock, Septic) : We have found that CRH enhanced lipopolysaccharide (LPS) induced tumor necrosis factor alpha (TNF-alpha) , interleukin-1beta (IL-1beta), and IL-6 production
Wang et al., J Neurochem 2003 (MAP Kinase Signaling System) : Corticotropin releasing hormone induces proliferation and TNF-alpha release in cultured rat microglia via MAP kinase signalling pathways ... In the present study, we show that CRH , acting on CRH-R1, promoted cell proliferation and tumour necrosis factor-alpha (TNF-alpha) release in cultured rat microglia ... In the presence of astressin, the effects of CRH on TNF-alpha release were attenuated ... CRH effects on TNF-alpha release were also inhibited by specific inhibitors of MEK, the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) ( PD98059 ) or p38 mitogen activated protein kinase ( SB203580 ), but not by H89 ... These results suggest that CRH induces cell proliferation and TNF-alpha release in cultured microglia via MAP kinase signalling pathways, thereby providing insight into the interactions between CRH and inflammatory mediators
Elenkov et al., J Neuroimmunol 1992 : Since NA released in the ME might be involved in the modulation of corticotropin releasing factor (CRF) production, it is suggested that TNF-alpha , through presynaptic modulation of NA release from noradrenergic nerve terminals in the ME, might regulate CRF and other neurohormone release in this hypothalamic structure
Maes et al., Neuro Endocrinol Lett 2003 : The aims of the present study were to examine i ) the effects of CRH , 10-9 M, 10 ( -8 ) M and 10 ( -7 ) M, on the stimulated production of IFNgamma, IL-10 and tumor necrosis factor-alpha (TNFalpha) by human whole blood ; and ii ) whether CRH, 10 ( -9 ) M, 10 ( -8 ) M and 10 ( -7 ) M, may antagonize some of the negative immunoregulatory effects of 5-HT, 1.5 microg/mL or 15 microg/mL ... CRH at all concentrations significantly blocked the 5-HT ( 1.5 microg/mL and 15 microg/mL ) -induced suppression of TNFalpha production
Ware et al., FEBS Lett 2005 : High CRH may be caused by increased central TNFalpha and IL-6 expression
Rysz et al., Am J Nephrol 2006 : The study aimed to differentiate the effects of hemodialysis ( HD ) and chronic renal failure (CRF) on the levels of circulating tumor necrosis factor-alpha (TNF-alpha) and TNF-alpha receptors p55 and p75, soluble vascular cell adhesion molecule-1 ( sVCAM-1 ), intercellular adhesion molecule-1 ( sICAM-1 ), soluble endothelial-leukocyte adhesion molecule-1 ( sE-selectin ) and sP-selectin in 18 patients on regular HD treatment with cuprophane membrane in relation to 15 non dialyzed CRF patients and 15 healthy controls
Navarra et al., Endocrinology 1991 : Neither IL-2 ( 1-10000 U/ml ), IL-8 ( 0.1-10 nM ), tumor necrosis factor ( 10-1000 U/ml ), interferon-alpha 2 ( 10-1000 U/ml ) nor interferon-gamma ( 10-1000 U/ml ) had any effect on hypothalamic CRH-41 release or pituitary ACTH release
Merola et al., Neuroendocrinology 1996 (Adenoma...) : In addition, CRH increased ACTH, beta-EPH and TNF alpha levels in the culture medium of three ACTH secreting tumors at the doses of 100 nmol/l and 1 mumol/l ( greater than 300, 200 and 110 % of baseline pretreatment incubation levels, respectively )
Panichi et al., Kidney Int 1998 (Kidney Failure, Chronic) : In vitro, TNF-alpha increased from 3.6 +/- 1.9 pg/cell to 1797 +/- 337 in N, from 4.5 +/- 1.7 to 1724 +/- 232 in CRF and from 3.4 +/- 2.3 to 1244 +/- 553 in HD after the LPS stimulus