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CCR1 — TNF

Text-mined interactions from Literome

Vecchi et al., J Leukoc Biol 1999 : TNF-alpha down-regulated CC chemokine receptor (CCR)1 , CCR2, and CCR5 and up-regulated CCR7 mRNA levels, in agreement with functional data
Sato et al., J Immunol 2000 : Stimulation of mature DCs with TGF-beta 1 also enhanced TNF-alpha induced down-regulation of the expressions of CCR-1 , CCR-3, CCR-5, CCR-6, and CXCR-4, and chemotaxis to their respective ligands, while this stimulation suppressed TNF-alpha induced expression of CCR-7 and chemotactic migratory ability to MIP-3 beta
Zhao et al., J Oral Pathol Med 2002 (Lichen Planus) : TNF-alpha stimulated CCR1 , CCR4 and CCR5 mRNA expression in the same cell line
Croitoru-Lamoury et al., Glia 2003 : Moreover, TNFalpha and IL-1beta significantly increase BOB/GPR15, CCR2 , and V28/CX3CR1 mRNA levels in both models
Amat et al., Br J Pharmacol 2006 (Arthritis) : However, results from both CCR1-deficient mice and human synovial membranes suggest that, in some experimental settings, blocking CCR1 could enhance TNF production
Ponte et al., Stem Cells 2007 : TNFalpha increases CCR2, CCR3 , and CCR4 expression ( as opposed to that of CXCR4 ), together with RANTES membrane binding
Joubert et al., J Immunol 2008 (Asthma) : Stimulation of ASMC with TNF-alpha and, to a lesser extent, IFN-gamma resulted in an up-regulation of CCR1 expression, which was totally suppressed by both dexamethasone or mithramycin
Fifadara et al., Int Immunol 2009 : CCR1 expression and signal transduction by murine BMMC results in secretion of TNF-alpha , TGFbeta-1 and IL-6
Catley et al., IDrugs 2010 (Asthma...) : This conference report highlights selected presentations on mAb treatments for asthma, including targeting IL-5, IL-13, IL-9 and TNFa , CCR3 inhibitors , histamine H4 receptor inhibition, novel mouse models of COPD and inhaled antisense asthma therapies