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F2R — IL8

Text-mined interactions from Literome

Asokananthan et al., J Immunol 2002 : PAR-1 , PAR-2, or PAR-4, in combination, caused additive IL-6 release, but only the PAR-1 and PAR-2 combination resulted in an additive IL-8 response
Lang et al., Invest Ophthalmol Vis Sci 2003 : HCE-T expression of cytokines ( IL-6, IL-8 , and TNFalpha ) in response to activation of PAR-1 and -2 was measured by quantitative RT-PCR and ELISA
Scholz et al., Int J Mol Med 2004 (Cytomegalovirus Infections) : Thrombin/PAR-1 mediated signaling stimulated PKC and NF-kappaB dependent IL-6 and IL-8 gene expression via phosphoinositide 3-kinase and further downstream via p42/44 and p38 MAPKs ... Thus, thrombin/PAR-1 mediated IL-6/IL-8 gene expression is uncoupled from Sp1 inhibition and may support proinflammatory pathomechanisms probably involved in hemorrhage/HCMV retinitis progression
Wang et al., Int J Biochem Cell Biol 2006 : It was reported that thrombin could induce IL-8 secretion from human dermal fibroblasts ( HDFs ) through activation of proteinase activated receptor (PAR)-1 ... It was found that HDFs express PAR-1 and PAR-3, and thrombin induces approximately 7.4-fold increase in IL-8 secretion from HDFs. Hirudin and a PAR-1 blocking antibody completely abolish the action of thrombin
Smadja et al., J Cell Mol Med 2009 : The effect of PAR-1 stimulation by the peptide SFLLRN on IL-8 , CXCR1 and CXCR2 expression was examined by RTQ-PCR and at the protein level in AB and CB late EPC and in AB early EPC ... Target-specific siRNA induced PAR-1 knockdown, and fully inhibited PAR-1 induced IL-8 synthesis ... In conclusion, PAR-1 activation induces IL-8 synthesis by late EPC
Melnikova et al., Cancer microenvironment : official journal of the International Cancer Microenvironment Society 2008 : Notably, in many tumor types including melanoma, PAR-1 expression directly correlates with their metastatic phenotype and is directly responsible for the expression of interleukin-8 , matrix metalloproteinase-2 (MMP-2), vascular endothelial growth factor, platelet derived growth factor, and integrins
Wang et al., FASEB J 2010 : In HT-29 colonic epithelial cells, PAR(1) or PAR(2) agonists stimulated the expression of IL-8 through a NF-kappaB dependent pathway without inducing IkappaB degradation and disassociation of IkappaB from NF-kappaB ... In conclusion, activation of either PAR(1) or PAR(2) stimulated the transcriptional up-regulation of IL-8 in HT-29 colonic epithelial cells through a pathway that involved ERK/RSK p90, NF-kappaB phosphorylation, and HAT activity
Cooper et al., PloS one 2011 (Inflammation) : Through the use of PAR-1 and PAR-2 neutralizing antibodies, it was determined that PAR-1 is essential for GrK induced IL-6, IL-8 and MCP-1 release
Kempkes et al., J Invest Dermatol 2012 (Melanoma...) : In conclusion, our results show that PAR(1) and PAR(2) are involved in WM9 cell proliferation and secretion of IL-8 by activation of PKD1
Osuga et al., Front Biosci (Elite Ed) 2012 (Endometriosis) : PAR1 activation in endometriotic stromal cells induces production of IL-8 , monocyte chemotactic protein-1, and cyclooxygenase-2, and proliferation of the cells
Osuga et al., Front Biosci (Schol Ed) 2012 (Endometriosis) : PAR1 activation in endometriotic stromal cells induces production of IL-8 , monocyte chemotactic protein-1, and cyclooxygenase-2, and proliferation of the cells
Ueno et al., Immunology 1996 : These results strongly suggest that catalytic activation of thrombin receptor by thrombin results in PKC dependent IL-8 production accompanied by an increase in IL-8 mRNA level