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CASP1 — TLR4
Text-mined interactions from Literome
Mariathasan et al., Nature 2004
(Inflammation...) :
Unexpectedly, Ipaf-deficient macrophages activated
caspase-1 in
response to
TLR plus ATP stimulation but not S. typhimurium
Lemmers et al., J Biol Chem 2007
(Rhabdoviridae Infections) :
In
response to
TLR4 stimulation,
caspase-8 is recruited to a complex containing IKKalphabeta, and its loss resulted in delayed NFkappaB nuclear translocation and impaired NFkappaB transcriptional activity
Hewinson et al., J Immunol 2008
(Ion Channel Gating) :
P2X(7) receptors ( P2X(7)Rs ) are ATP gated ion channels that trigger
caspase-1 activation in the
presence of
TLR ligands
Netea et al., Blood 2009
(Inflammation) :
Controversy has arisen whether
Toll-like receptor ( TLR ) ligands alone can
activate caspase-1 for release of interleukin-1beta (IL-1beta)
Hurst et al., Immunobiology 2009
(Antiphospholipid Syndrome) :
Determination of expression-levels using real-time RT-PCR showed significantly augmented
TLR dependent IL-1beta and
caspase-1 expression
Nowicki et al., J Neurosci Res 2010
:
The inhibition of
TLR4 caused activation of jun N-terminal kinase ( JNK ) and a significant decrease of cleaved
caspase-3 but did not change the TLR4 level
Harder et al., J Immunol 2009
(Disease Models, Animal...) :
Notably,
activation of
caspase-1 by TLR2 and
TLR4 ligands in the presence of streptolysin O required Myd88/Trif, whereas that induced by S. pyogenes was blocked by inhibition of NF-kappaB