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PAK1 — PI3
Text-mined interactions from Literome
Chaudhary et al., Curr Biol 2000
:
Furthermore, integrin induced activation of the serine/threonine kinase
Pak-1 , which has been shown to phosphorylate Raf1 Ser338, was also
dependent on
PI 3-kinase activity and expression of a kinase-inactive Pak-1 mutant blocked phosphorylation of Raf1 Ser338
Diakonova et al., Mol Biol Cell 2002
:
The
PI 3-kinase inhibitor wortmannin did not change the dynamics of PI 3-kinase or ezrin localization but
prevented the loss of
PAK1 from phagosomes
Menard et al., Cell Signal 2003
:
Activation of
PAK1 by LPA was
independent of
PI3-kinase and the EGF receptor, but was inhibited by dominant negative RhoA
Jung et al., Eur J Biochem 2004
(Melanoma) :
Treatment of human melanoma cells A2058 with LPA increased phosphorylation and activation of
PAK1 , which was
blocked by treatment with pertussis toxin and by inhibition of
phosphoinositide 3-kinase (PI3K) with an inhibitor LY294002 or by overexpression of catalytically inactive mutant of PI3Kgamma, indicating that LPA induced PAK1 activation was mediated via a Gi protein and the PI3Kgamma signaling pathway
Mao et al., J Mol Cell Cardiol 2008
(Hypertrophy) :
Both
Pak1 and Akt can be activated by multiple hypertrophic stimuli or growth factors in a
phosphatidylinositol-3-kinase (PI3K) dependent manner
Jones et al., J Biol Chem 1998
:
Similarly, immune complex
activation of the Rac/Cdc42 dependent serine/threonine kinase
Pak1 is blocked by
PI 3-kinase inhibitors, but fMLP induced activation is not