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JUN — VDR

Pathways - manually collected, often from reviews:

• FastForward regulation: JUN → VDR (transcriptional regulation, increase) Qi et al., J Biol Chem 2002*
  Evidence: PROMACTIVITY, DNABINDING
• FastForward regulation: FOS, JUN → VDR (transcriptional regulation, increase) Qi et al., J Biol Chem 2002*
  Evidence: PROMACTIVITY, DNABINDING

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: VDR — JUN (direct interaction, pull down) Towers et al., Mol Cell Biol 1999*
• IRef Hprd Interaction: VDR — JUN (in vitro) Towers et al., Mol Cell Biol 1999*
• IRef Ophid Interaction: VDR — JUN (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: VDR — JUN (aggregation, confirmational text mining) Towers et al., Mol Cell Biol 1999*

Text-mined interactions from Literome

Jiménez-Lara et al., J Biol Chem 1999 : Furthermore, the VDR mutants, but not the native receptor, enhanced phorbol ester induction of the activator protein-1 containing collagenase promoter
Li et al., J Biol Chem 2007 : Stress induced c-Jun dependent Vitamin D receptor (VDR) activation dissects the non-classical VDR pathway from the classical VDR activity ... Here we show that c-Jun is essential for VDR expression and VDR in turn inhibits c-Jun dependent cell death by non-classical mechanisms ... The necessary and sufficient role of c-Jun in VDR expression was established by the fact that c-Jun knock-out decreases VDR expression, whereas c-Jun restoration recovers its activity ... c-Jun is also required for vitamin D ( 3 ) -induced classical VDR transcriptional activity by a mechanism likely involving physical interactions between c-Jun and VDR proteins
Wu et al., Cancer Lett 2007 (MAP Kinase Signaling System) : 1alpha,25-Dihydroxyvitamin D ( 3 ) antiproliferative actions involve vitamin D receptor mediated activation of MAPK pathways and AP-1/p21 ( waf1 ) upregulation in human osteosarcoma