Gene interactions and pathways from curated databases and text-mining

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IRF6 — PECAM1

Text-mined interactions from Literome

Rui et al., J Immunol 2007 : However, the role and the mechanisms of PECAM-1 in the regulation of TLR4 mediated LPS response in macrophages remain unclear ... Taken together with the data that PECAM-1 is constitutively expressed in macrophages and its expression is up-regulated by LPS stimulation, PECAM-1 might function as a feedback negative regulator of LPS inflammatory response in macrophages
Hebeda et al., Clin Exp Immunol 2011 (Inflammation) : Here, the molecular mechanism by which NO regulates lipopolysaccharide (LPS) induced endothelial PECAM-1 expression and the role of interleukin (IL)-10 on this control was investigated ... Supernatant of LPS stimulated lymphocytes obtained from L-NAME treated rats, which contained higher levels of IL-10, reduced LPS induced PECAM-1 expression by endothelial cells, and this reduction was reversed by adding the anti-IL-10 monoclonal antibody