◀ Back to CD8A
CD3E — CD8A
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Downstream signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
JUN (JUN)
(modification, activates)
-
NCI Pathway Database Downstream signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
JNK1 (MAPK8)
(modification, activates)
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
CSK/PAG1 complex (CSK-PAG1)
→
TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70)
(modification, collaborate)
Brdicka et al., J Exp Med 2000
Evidence: assay, physical interaction
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70)
→
Csk (CSK)
(modification, activates)
Brdicka et al., J Exp Med 2000
Evidence: assay, physical interaction
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
B7 family/CD28 complex (CD28-CD80_CD86)
(modification, collaborate)
Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Anel et al., Eur J Immunol 1996
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
LCK (LCK)
(modification, collaborate)
Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Anel et al., Eur J Immunol 1996
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK)
(modification, collaborate)
Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Anel et al., Eur J Immunol 1996
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
B7 family/CD28 complex (CD28-CD80_CD86)
→
TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK)
(modification, activates)
Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Anel et al., Eur J Immunol 1996
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
LCK (LCK)
→
TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK)
(modification, collaborate)
Housden et al., Eur J Biochem 2003, Barber et al., Proc Natl Acad Sci U S A 1989, van Oers et al., J Exp Med 1996, Anel et al., Eur J Immunol 1996
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70)
→
SHC (SHC1)
(modification, activates)
Walk et al., Eur J Immunol 1998
Evidence: expresssion pattern
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
Perforin 1 (PRF1)
(transcription, activates)
Curtsinger et al., J Exp Med 2003
Evidence: assay, other species
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
B7 family/CD28 complex (CD28-CD80_CD86)
(transcription, activates)
Curtsinger et al., J Exp Med 2003
Evidence: assay, other species
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
Monovalent TCR/CD3 complex (CD247-CD3E-CD3G-CD3D)
(modification, collaborate)
Call et al., Cell 2002, Yachi et al., Nat Immunol 2005, O'Rourke et al., Nature 1990, Luescher et al., Nature 1995, Sykulev et al., Immunity 1996, Anel et al., J Immunol 1997
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
CD8 heterodimer complex (CD8A-CD8B)
(modification, collaborate)
Call et al., Cell 2002, Yachi et al., Nat Immunol 2005, O'Rourke et al., Nature 1990, Luescher et al., Nature 1995, Sykulev et al., Immunity 1996, Anel et al., J Immunol 1997
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
peptide-MHC class I complex (HLA-A-B2M)
(modification, collaborate)
Call et al., Cell 2002, Yachi et al., Nat Immunol 2005, O'Rourke et al., Nature 1990, Luescher et al., Nature 1995, Sykulev et al., Immunity 1996, Anel et al., J Immunol 1997
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
Monovalent TCR/CD3 complex (CD247-CD3E-CD3G-CD3D)
→
CD8 heterodimer complex (CD8A-CD8B)
(modification, collaborate)
Call et al., Cell 2002, Yachi et al., Nat Immunol 2005, O'Rourke et al., Nature 1990, Luescher et al., Nature 1995, Sykulev et al., Immunity 1996, Anel et al., J Immunol 1997
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
CBL (CBL)
→
TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70)
(modification, collaborate)
Davanture et al., J Immunol 2005
Evidence: mutant phenotype, other species
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
CBL (CBL)
→
TCR/CD3/MHC I/CD8/LCK/ZAP-70/CBL/ubiquitin complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70-CBL)
(modification, collaborate)
Davanture et al., J Immunol 2005
Evidence: mutant phenotype, other species
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70)
→
TCR/CD3/MHC I/CD8/LCK/ZAP-70/CBL/ubiquitin complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70-CBL)
(modification, collaborate)
Davanture et al., J Immunol 2005
Evidence: mutant phenotype, other species
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
LAT/GRAP2/SLP76/VAV1 complex (LAT-GRAP2-LCP2-VAV1)
→
TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK)
(modification, collaborate)
Reynolds et al., J Exp Med 2002, Fukazawa et al., J Biol Chem 1995, Carrera et al., J Biol Chem 1994, Exley et al., J Biol Chem 1994, de Aós et al., J Biol Chem 1997, Zhang et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database Downstream signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
IL2 (IL2)
(modification, activates)
-
NCI Pathway Database Downstream signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
IL2R complex (IL2RA-IL2RB-IL2RG)
(modification, activates)
-
NCI Pathway Database Downstream signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
IL2/IL2R complex (IL2RA-IL2RB-IL2RG-IL2)
(modification, activates)
-
NCI Pathway Database Downstream signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
IL2R gamma (IL2RG)
(modification, activates)
Akbar et al., Eur J Immunol 1996
Evidence: mutant phenotype
-
NCI Pathway Database Downstream signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
IL2R gamma cytokines/IL2R gamma complex (IL2RG)
(modification, activates)
Akbar et al., Eur J Immunol 1996
Evidence: mutant phenotype
-
NCI Pathway Database IL12-mediated signaling events:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
EOMES (EOMES)
(transcription, activates)
Takemoto et al., J Immunol 2006
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL12-mediated signaling events:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Takemoto et al., J Immunol 2006
Evidence: mutant phenotype, other species
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
Fyn (FYN)
(modification, collaborate)
van't Hof et al., J Cell Biol 1999, Samelson et al., Proc Natl Acad Sci U S A 1990
Evidence: assay, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
TCR/CD3/MHC I/CD8/Fyn complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-FYN)
(modification, collaborate)
van't Hof et al., J Cell Biol 1999, Samelson et al., Proc Natl Acad Sci U S A 1990
Evidence: assay, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
Fyn (FYN)
→
TCR/CD3/MHC I/CD8/Fyn complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-FYN)
(modification, collaborate)
van't Hof et al., J Cell Biol 1999, Samelson et al., Proc Natl Acad Sci U S A 1990
Evidence: assay, physical interaction, other species
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70)
→
ZAP-70 (ZAP70)
(modification, collaborate)
Iwashima et al., Science 1994
Evidence: assay, physical interaction
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70)
→
TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK)
(modification, collaborate)
Iwashima et al., Science 1994
Evidence: assay, physical interaction
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
B7 family/CD28 complex (CD28-CD80_CD86)
→
TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK)
(modification, activates)
Iwashima et al., Science 1994
Evidence: assay, physical interaction
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
ZAP-70 (ZAP70)
→
TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK)
(modification, collaborate)
Iwashima et al., Science 1994
Evidence: assay, physical interaction
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
LAT/GRAP2/SLP76/VAV1/PI3K Class IA complex (LAT-GRAP2-LCP2-VAV1)
→
TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70)
(modification, activates)
Villalba et al., J Cell Biol 2002, Reynolds et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70)
→
PKC theta (PRKCQ)
(modification, activates)
Villalba et al., J Cell Biol 2002, Reynolds et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database TCR signaling in naïve CD8+ T cells:
TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70)
(modification, activates)
Villalba et al., J Cell Biol 2002, Reynolds et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
Reactome Reaction:
CD3E
→
CD8A
(indirect_complex)
Text-mined interactions from Literome
Turka et al., J Immunol 1991
:
Taken together, our data suggest a model of thymic development in which CD4 or
CD8 may
enhance TCR/CD3 signaling upon coligation by an MHC molecule
Zhong et al., PloS one 2009
:
The ligation of
TCR/CD3 on CD4 or CD8 T cells
led to CD3 nanoscale co-clustering or interaction with CD4 or
CD8 co-receptors forming 200-500 nm nano-domains or > 500 nm micro-domains