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PDLIM7 — RELA

Text-mined interactions from Literome

Fischer et al., Virus Res 1999 (Cell Transformation, Viral...) : The results suggested that whereas differences in the activation of NF-kappaB through the various LMP1 isolates correlated tightly with their different expression levels, the outgrowth of transfected cells in soft agar did not and the transcription factor NF-kappaB therefore appeared not to be the major effector for the transformation of the rodent cell line ratl by LMP1
Kieser et al., EMBO J 1999 (Cell Transformation, Neoplastic) : Whereas NF-kappaB activation by LMP1 was blocked by a dominant negative TRADD mutant, LMP1 induces JNK1 independently of the TRADD death domain and TRAF2, which binds to TRADD
Eliopoulos et al., J Biol Chem 1999 : Divergence of signals must, however, occur downstream of TRAF2 as a dominant negative TRAF2 mutant that blocks LMP1 induced NF-kappaB activation also inhibited p38 signaling
Izumi et al., Mol Cell Biol 1999 (Burkitt Lymphoma...) : Further, LMP1 does not require TRADD residues 294 to 312 for NF-kappaB activation, while TNFR1 requires TRADD residues 296 to 302 ... Surprisingly, LMP1 does not require RIP for NF-kappaB activation
Puls et al., J Cell Sci 1999 (Inflammation) : Using LMP1 mutants, we show that activation of Cdc42 and JNK/NF(kappa)B occur through distinct pathways and that Cdc42 activation is independent of LMP1 's interaction with TRADD and TRAF proteins
Izumi et al., J Virol 1999 (Cell Transformation, Viral) : LMP1 spontaneously aggregates in the plasma membrane and enables two transformation effector sites ( TES1 and TES2 ) within the 200-amino-acid cytoplasmic carboxyl terminus to constitutively engage the tumor necrosis factor receptor (TNFR) associated factors TRAF1, TRAF2, TRAF3, and TRAF5 and the TNFR associated death domain proteins TRADD and RIP, thereby activating NF-kappaB and c-Jun N-terminal kinase (JNK)
Cahir McFarland et al., Oncogene 1999 (Cell Transformation, Viral) : Thus, EBV mediated growth transformation is genetically and biochemically linked to LMP1 mediated activation of NF-kappaB
Erickson et al., J Virol 2000 : Although lyLMP-1 itself has negligible effects on NF-kappaB activity, it inhibits NF-kappaB activation by LMP-1 in a dose dependent manner
Tabata YHibi et al., Leukemia & lymphoma 2000 (Carcinoma...) : NF-kappaB assay revealed that HLH-LMP1 activated NF-kappaB significantly more than that of B95.8-LMP1 ( p=0.032 )
Brennan et al., J Biol Chem 2001 : It inhibits LMP1 stimulated NFkappaB , STAT, and Jun transcriptional activity
Vockerodt et al., Virology 2001 (Burkitt Lymphoma...) : Inhibition of LMP1 mediated NF kappa B activation by constitutive repressive I kappa B-alpha only marginally impaired IL-10 expression in BL2 cells, while SB2035080 at 5 microM ( a specific p38/SAPK2 inhibitor ) led to reduced IL-10 expression
Luftig et al., J Biol Chem 2001 : We now find that NF-kappaB activation by Epstein-Barr virus latent membrane protein 1 (LMP1) or by an LMP1 transmembrane domain chimera with the LTbetaR signaling domain in human embryonic kidney 293 cells is selectively inhibited by a wild type dominant negative NIK comprised of amino acids 624-947 ( DN-NIK ) and not by aly DN-NIK ... LMP1 , an LMP1 transmembrane domain chimera with the LTbetaR signaling domain, and LMP1/CD40 activate NF-kappaB in wt or aly murine embryo fibroblasts ... These data are compatible with a model in which activation of NF-kappaB by LMP1 and LTbetaR is mediated by an interaction of NIK or a NIK-like kinase with IKKalpha that is abrogated by the aly mutation
Busch et al., J Immunol 2001 : However, studies of transiently overexpressed LMP1 molecules, primarily in epithelial cells, indicated that a second region, CTAR2, is largely responsible for LMP1 mediated activation of NF-kappaB and c-Jun N-terminal kinase
Yin et al., Chin Med J (Engl) 2001 (Nasopharyngeal Neoplasms) : LMP1 activates NF-kappa B via degradation of I kappa B alpha in nasopharyngeal carcinoma cells ... After the introduction of the dominant negative mutant of I kappa B alpha ( Del 71 ) into Tet-on-LMP1-HNE2 cells, both nuclear translocation and transactivation of NF-kappa B induced by LMP1 was significantly inhibited ... The results indicated that in nasopharyngeal carcinoma cells, LMP1 activated NF-kappa B via phosphorylation and degradation of I kappa B alpha, but not I kappa B beta ... The dominant negative mutant of I kappa B alpha ( Del 71 ) could completely inhibit both the nuclear translocation and transactivation of NF-kappa B induced by LMP1
Rothenberger et al., Cell Mol Life Sci 2002 : Moreover, Ndelta25 inhibited WT LMP1 mediated induction of the transcription factors NF-kappaB and AP-1
Eliopoulos et al., J Virol 2002 (Carcinoma...) : LMP1 promotes NF-kappaB activation through the recruitment of the adapter protein TRAF2 and the formation of a dynamic multiprotein complex that includes the NF-kappaB kinase, the IkappaB kinases, and their downstream targets, IkappaBs and p105 ... In this study, we have identified the oncogenic kinase Tpl-2/Cot as a novel component of LMP1 induced NF-kappaB signaling ... Inducible expression of LMP1 promotes the activation of Tpl-2, and a catalytically inactive Tpl-2 mutant suppresses LMP1 induced NF-kappaB signaling ... The ability of Tpl-2 to influence LMP1 induced NF-kappaB occurs through modulation of both IkappaBalpha and p105 functions
Wang et al., Zhonghua Zhong Liu Za Zhi 2002 (Nasopharyngeal Neoplasms) : In the meantime, efforts were made to demonstrate if LMP1 regulates NF-kappa B or AP-1 activation using reporter gene analysis
Yoshizaki et al., Histol Histopathol 2002 (Carcinoma...) : LMP-1 down-regulates expression of E-cadherin, induces matrix metalloproteinase-9 and urokinase type-plasminogen activator through activation of NF-kappaB and AP-1, and enhances cell motility via ets-1 activation ... LMP-1 also induces vascular endothelial growth factor through cyclooxygenase-2 activation and interleukin-8 through NF-kappaB activation
Chung et al., J Biol Chem 2002 : We show that BRAM1 interferes with LMP1 mediated NF-kappaB activation but not the JNK signaling pathway
Fukuda et al., Virology 2002 (Cell Transformation, Neoplastic...) : EBV latent membrane protein 1 (LMP1) induced constitutive ERK 1/2 phosphorylation and NF-kappa B activation in LMP1 transfected HSC-39 cells, which then became resistant to TGF-beta 1-mediated growth inhibition, TGF-beta 1-mediated ERK 1/2 phosphorylation, and p21 induction, and proliferated in low-serum medium
Coffin et al., J Virol 2003 : Additionally, lipid raft association, mediated by transmembrane domains 1 and 2, plays a significant role in LMP-1 activation, and LMP-1 can activate NF-kappaB via an oligomerization/TRAF binding independent mechanism
Nitta et al., Cell Signal 2003 (Cell Transformation, Viral) : Moreover, LMP1 induced activation of caspase-3 via the activation of NF-kappaB
Erickson et al., J Virol 2003 (Epstein-Barr Virus Infections) : Although lyLMP-1 shares none of LMP-1 's transforming and signal transducing activities, we recently reported that lyLMP-1 can negatively regulate LMP-1 stimulated NF-kappaB activation
Lee et al., Int J Hematol 2003 (Hodgkin Disease) : In HL pathogenesis associated with Epstein-Barr virus infection, the activation of NF-kappaB is induced by viral latent membrane protein 1 (LMP1)
Hsieh et al., Cancer Gene Ther 2003 : Previous studies indicate that a strategy combining LMP1 mediated NF-kappaB activation and the HSV thymidine kinase/Ganciclovir ( HSVtk/GCV ) prodrug system leads to regression of tumor growth in nude mice
Tang et al., J Biol Chem 2003 : Our data suggest that LMP1-95-8 is a pseudo-substrate of SCFHOS/betaTrCP E3 ubiquitin ligase and that interaction between LMP1 and HOS restricts the extent of LMP1 induced NF-kappaB signaling
Eliopoulos et al., Oncogene 2003 : LMP1 induced NF-kappaB transactivation is reduced in nf-kb2 ( -/- ) mouse embryo fibroblasts, suggesting that p100 processing contributes to LMP1 mediated NF-kappaB transcriptional effects
Gennari et al., J Mol Biol 2004 : Further assessment of the biological activity of the anti-TES1 intrabody pools demonstrated that they were all able to selectively block F-LMP1 induced NFkappaB activity that was mediated through the TES1-site and to bind LMP1 protein with high efficiency
Luftig et al., Proc Natl Acad Sci U S A 2003 : Epstein-Barr virus latent membrane protein 1 (LMP1) activation of NF-kappaB is critical for Epstein-Barr virus infected B lymphocyte survival ... LMP1 activates the IkappaB kinase complex and NF-kappaB through two cytoplasmic signaling domains that engage tumor necrosis factor receptor associated factor ( TRAF)1/2/3/5 or TRADD and RIP ... LMP1 activates the IkappaB kinase complex and NF-kappaB through two cytoplasmic signaling domains that engage tumor necrosis factor receptor associated factor ( TRAF)1/2/3/5 or TRADD and RIP ... We now use cells lacking expression of TRAF2, TRAF5, TRAF6, IKKalpha, IKKbeta, IKKgamma, TAB2, IL-1 receptor associated kinase (IRAK)1, or IRAK4 to assess their roles in LMP1 mediated NF-kappaB activation ... LMP1 induced RelA nuclear translocation was similar in IKKalpha knockout ( KO ) and WT murine embryo fibroblasts ( MEFs ) but substantially deficient in IKKbeta KO MEFs ... Consistent with the importance of TRAF6, LMP1 induced NF-kappaB activation in HEK293 cells was inhibited by expression of dominant negative TAB2 and Ubc13 alleles ... These data extend a role for IKKalpha in IKKbeta regulation, identify an unusual IKKbeta dependent and IKKgamma independent NF-kappaB activation, and indicate that IRAK1 and TRAF6 are essential for LMP1 induced NF-kappaB activation
Luftig et al., Proc Natl Acad Sci U S A 2004 : LMP1 activates NF-kappaB , in part, by engaging tumor necrosis factor (TNF) receptor associated factors ( TRAFs ), which also mediate NF-kappaB activation from LTbetaR and CD40 ... Thus, LMP1 induces typical canonical IKKbeta/IKKgamma dependent, atypical canonical IKKbeta-dependent/IKKgamma independent, and noncanonical NIK/IKKalpha dependent NF-kappaB activations ; NIK/IKKalpha dependent NF-kappaB activation is principally mediated by the LMP1 TRAF binding site
Yasui et al., Proc Natl Acad Sci U S A 2004 : LMP1TM1-2 enabled approximately 40 % of wild-type LMP1 cytoplasmic domain mediated NF-kappaB activation, whereas TM3-4 or TM5-6 assayed in parallel had almost no effect independent of LMP1TM1-2 ... Because FWLY ( 38-41 ) was essential for LMP1 mediated signal transduction, and LMP1 activation of NF-kappaB is essential for proliferating B lymphocyte survival, inhibition of LMP1FWLY ( 41 ) -mediated LMP1/LMP1 intermolecular interactions is an attractive therapeutic target
Lo et al., Int J Cancer 2004 (Nasopharyngeal Neoplasms) : 2117-LMP1 could activate higher level of NF-kappaB activity in HEK 293 cells than B95.8-LMP1
Cahir-McFarland et al., J Virol 2004 : The role of NF-kappa B in LMP1 and overall EBV latency III transcriptional effects was investigated by treating LCLs with BAY11-7082 ( BAY11 )
Tao et al., Cell Signal 2004 : Inhibition of LMP1 mediated NFkappaB activation by constitutive repressive IkappaBalpha marginally decreased EGFR promoter activity using transiently transfected IkappaBalpha dominant negative mutant
Ren et al., Laryngoscope 2004 (Carcinoma...) : LMP1 induces IL-8 mainly through the activation of NF-kappa B and partly through AP-1 in NPC model cell lines, NPC-KT, and this suggests that LMP1 plays an important role in the angiogenesis of NPC
Tao et al., Virus Res 2004 : Nuclear factor kappa B (NFkappaB) dependent modulation of Epstein-Barr virus latent membrane protein 1 (LMP1) in epidermal growth factor receptor (EGFR) promoter activity ... Inhibition of LMP1 mediated NFkappaB activation by constitutive repressive inhibitory kappa B alpha ( IkappaBalpha ) marginally decreased EGFR promoter activity using transiently transfected IkappaBalpha dominant negative mutant
Everly et al., J Virol 2004 (Cell Transformation, Viral) : Latent membrane protein 1 (LMP1) , the Epstein-Barr virus oncoprotein, activates NF-kappaB , phosphatidylinositol 3-kinase, mitogen activated protein kinase, and c-Jun N-terminal kinase signaling
Grimm et al., Blood 2005 (Epstein-Barr Virus Infections) : BAX expression was regulated by LMP-1 activation of nuclear factor kappaB (NF-kappaB) via the C-terminal activation region 1 ( CTAR-1 ) and CTAR-2
Larousserie et al., Am J Pathol 2005 (Epstein-Barr Virus Infections...) : EBI3 is expressed at high levels in EBV transformed B-cell lines and is induced in vitro by the EBV oncogene LMP1 in a nuclear factor (NF)-kappaB dependent manner
Pfuhl et al., Hum Genet 2005 (Mammary Neoplasms, Animal) : As the DGCR6 protein ( s ) influence gene expression in trans, we analysed the influence of DGCR6/DGCR6L on the Epstein-Barr virus encoded oncoproteins EBNA2 and EBNA3c in the activation of the viral LMP1 promoter, as well as LMP1 mediated activation of NFkB , but found no effect in either setting
Swanson-Mungerson et al., J Virol 2005 : Furthermore, LMP2A induces NF-kappaB nuclear translocation independent of BCR cross linking
Thornburg et al., Oncogene 2006 (Lymphoma) : LMP1 signaling and activation of NF-kappaB in LMP1 transgenic mice
Wu et al., J Biol Chem 2006 (Cell Transformation, Neoplastic) : Furthermore, we showed that TAK1 is required for NF-kappaB activation by LMP1
Poppema et al., Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2005 (Hodgkin Disease) : A key role is played by the presence of constitutive nuclear factor (NF)-kappaB , which is induced by LMP1 , as well as by CD30, CD40, tumor necrosis factor (TNF)-alpha, and Notch1 interactions, and results in the upregulation of at least 45 genes including chemokines, cytokines, receptors, apoptotic regulators, intracellular signaling molecules, and transcription factors
Le Clorennec et al., Blood 2006 (Cell Transformation, Viral...) : Therefore, LMP1 activation of NF-kappaB sensitizes infected B cells to CD95 mediated apoptosis and renders EBV latency III immortalized B cells susceptible to elimination by the immune system, contributing to the establishment of a host/virus equilibrium
Uemura et al., J Biol Chem 2006 : Epstein-Barr virus latent membrane protein 1 (LMP1) activates NF-kappaB and c-Jun N-terminal kinase (JNK), which is essential for LMP1 oncogenic activity ... Genetic analysis has revealed that tumor necrosis factor receptor associated factor 6 ( TRAF6 ) is an indispensable intermediate of LMP1 signaling leading to activation of both NF-kappaB and JNK ... Furthermore, we found that ablation of TAK1 resulted in the loss of LMP1 induced activation of JNK but not of NF-kappaB
Xu et al., J Biol Chem 2006 (Burkitt Lymphoma) : LMP-1 mediated activation of NF-kappaB is apparently necessary and sufficient for LMP-1 mediated priming effect in DG75 cells, a human B cell line
Song et al., Proc Natl Acad Sci U S A 2006 : Because IRAK1 is upstream of TRAF6 in IL-1 activation of NF-kappaB, the potential role of IRAK1 in LMP1 mediated NF-kappaB activation through TRAF6 and inhibitor of kappaB (IkappaB) kinase ( IKK ) was initially investigated ... Thus, the critical IRAK1 role in LMP1 induced NF-kappaB activation is in mediating p65/RelA S536 phosphorylation through an effect on p38 or other p65 S536 kinases
Liu et al., EMBO J 2006 : Latent membrane protein 1 (LMP1) , which is an Epstein-Barr virus ( EBV ) -encoded oncoprotein, induces nuclear factor-kappa B (NF-kappaB) signaling by mimicking the tumor necrosis factor receptor (TNFR) ... Here, we identify a new LMP1 interacting molecule, prenylated Rab acceptor 1 (PRA1), which interacts with LMP1 for the first time through LMP1 's transmembrane domain, and show that PRA1 is involved in intracellular LMP1 trafficking and LMP1 induced NF-kappaB activity ... Immunofluorescence and biochemical analyses revealed that LMP1 physically interacted with PRA1 at the Golgi apparatus, and the colocalization of LMP1 and PRA1 to the Golgi was sensitive to nocodazole and brefeldin A. Coexpression of a PRA1 export mutant or knockdown of PRA1 led to redistribution of LMP1 and its associated signaling molecules to the endoplasmic reticulum and subsequent impairment of LMP1 induced NF-kappaB activation, but had no effect on CD40- and TNFR1 mediated signaling or the functional integrity of the Golgi apparatus
Zhang et al., Chin J Cancer 2007 (Cell Transformation, Neoplastic...) : When pLNSX-LMP1 and pBabe-IkappaB were cotransfected at a ratio of 1 : 1, IkappaBalpha inhibited LMP1 mediated NF-kappaB activation by 75 % û and at a ratio of 3 : 1, it almost completely inhibited LMP1 mediated NF-kappaB activation
Fang et al., Intervirology 2007 : One of the scFv clones, designated H3, was capable of reducing LMP1 mediated NF-kappaB activation in HEK293 cells
Thornburg et al., J Virol 2007 : LMP1 has two domains that both activate NF-kappaB
Guasparri et al., Blood 2008 (Cell Transformation, Viral...) : EBV LMP2A affects LMP1 mediated NF-kappaB signaling and survival of lymphoma cells by regulating TRAF2 expression ... We found that suppression of LMP1 by RNA interference results in inhibition of basal NF-kappaB and induction of apoptosis
Le Clorennec et al., J Virol 2008 : Therefore, our results are in agreement with a model where LMP1 dependent NF-kappaB activation induces Fas overexpression and autoactivation that could overwhelm the antiapoptotic effect of NF-kappaB, revealing an ambivalent function of LMP1 in cell survival and programmed cell death
Ikeda et al., Mol Cell Biol 2008 : In the present study, we found that ectopic expression of STAP-2 inhibited Epstein-Barr virus ( EBV ) LMP1 mediated NF-kappaB signaling and interleukin-6 expression ... We found, furthermore, that STAP-2 regulated LMP1 mediated NF-kappaB signaling through direct or indirect interactions with the tumor necrosis factor receptor (TNFR) associated factor 3 ( TRAF3 ) and TNFR associated death domain (TRADD) proteins
Shair et al., Cancer Res 2008 : However, constitutive activation of Akt alone did not alter cell growth, suggesting that both PI3K/Akt and NF-kappaB activation are required by LMP1
Song et al., Proc Natl Acad Sci U S A 2008 : Association with active LMP1 signaling complexes was also critical for IRF7 activation because (i) a dominant negative IRF7 bound to LMP1, blocked IRF7 association and activation, but did not inhibit LMP1 induced NF-kappaB or TBK1 or Sendai virus mediated IFN stimulated response element activation ; and ( ii ) two different LMP1 transmembrane domain mutants, which fail to aggregate, each bound IRF7 and prevented LMP1 from binding and activating IRF7 in the same cell, but did not prevent NF-kappaB activation
Demetriades et al., J Virol 2009 : The LMP1 promoter can be transactivated directly by NF-kappaB ... p65RelA could also induce LMP1 expression from the EBV genome in Daudi and P3HR1 Burkitt 's lymphoma cell lines
Ikeda et al., FEBS Lett 2009 : BS69 negatively regulates the canonical NF-kappaB activation induced by Epstein-Barr virus derived LMP1 ... In the present study, our manipulation of BS69 expression clearly indicates that BS69 negatively regulates LMP1 mediated NF-kappaB activation and up-regulates IL-6 mRNA expression and IkappaB degradation
Liu et al., Molecular cancer 2009 (Nasopharyngeal Neoplasms) : These results suggest that human iE kappa is active in Ig kappa expressing NPC cells and LMP1 stimulated NF-kappaB and AP-1 activation results in an augmenting activation of the iE kappa
Liu et al., Bone 2010 : Osteoinductive LIM mineralization protein-1 suppresses activation of NF-kappaB and selectively regulates MAPK pathways in pre-osteoclasts
Ikeda et al., FEBS Lett 2010 : BS69 cooperates with TRAF3 in the regulation of Epstein-Barr virus derived LMP1/CTAR1 induced NF-kappaB activation ... Previous studies have demonstrated that BS69, a multidomain cellular protein, regulates LMP1/CTAR2 mediated NF-kappaB activation by interfering with the complex formation between TRADD and LMP1/CTAR2 ... Here, we found that BS69 directly interacted with the LMP1/CTAR1 domain and regulated LMP1/CTAR1 mediated NF-kappaB activation and subsequent IL-6 production ... Furthermore, small interfering RNA mediated knockdown experiments revealed that TRAF3 was involved in the BS69 mediated suppression of LMP1/CTAR1 induced NF-kappaB activation
Lin et al., Cytokine 2010 : Our findings thus suggest that PKR plays an important role in mediating the cytokine gene expression induced by LMP1 through NF-kappaB activation and histone H3 Ser 10 phosphorylation
Sekine et al., Yakugaku Zasshi 2010 : Moreover, STAP-2 interacts with Epstein-Barr virus derived LMP1 and modulates LMP1 mediated NF-kappaB signaling
Song et al., Virus Genes 2010 : Epstein-Barr virus ( EBV ) latent membrane protein 1 (LMP1) induced NF-kappaB activation is essential for EBV transformed B cell survival ... Using IKKalpha ( -/- ), IKKbeta ( -/- ), IKKgamma ( -/- ), TRAF2 ( -/- ), TRAF3 ( -/- ), TRAF6 ( -/- ), and NIK ( aly/aly ) mouse embryonic fibroblasts ( MEFs ), potential roles of these proteins in LMP1 induced alternative NF-kappaB activation were investigated
Huen et al., Oncogene 1995 : The Epstein-Barr virus latent membrane protein-1 (LMP1) mediates activation of NF-kappa B and cell surface phenotype via two effector regions in its carboxy-terminal cytoplasmic domain
Herrero et al., J Virol 1995 : NF-kappa B , a transcription factor controlling the expression of genes involved in cell activation and growth control, has been shown to be activated by LMP-1
Knecht et al., Oncogene 1996 (Carcinoma...) : Therefore, LMP1 mediated NF-kappa B activation appears to be involved in polycaria formation
Devergne et al., Mol Cell Biol 1996 (Cell Transformation, Viral) : NF-kappaB activation by LMP1 ( 1-231 ) is likely to be mediated by TRAF1/TRAF2 heteroaggregates since TRAF1 is unique among the TRAFs in coactivating NF-kappaB with LMP1 ( 1-231 ), a TRAF2 dominant negative mutant can block LMP1 ( 1-231 ) -mediated NF-kappaB activation as well as TRAF1 coactivation, and 30 % of TRAF2 is associated with TRAF1 in EBV transformed B cells
Floettmann et al., Oncogene 1997 : These inducible chimeric proteins also allowed us to demonstrate that LMP1 mediated NF-kappaB activation is an immediate event following activation of LMP1
Yeh et al., DNA Cell Biol 1997 (Cell Transformation, Viral) : In this study, we tested if this 10-amino-acid deletion affected the induction of NF-kappaB activity by LMP 1
Johnson et al., J Virol 1998 : Activation of NF-kappaB by CAO-LMP1 was not impaired in any of the lines ; rather, activation of an NF-kappaB reporter by CAO-LMP1 was consistently about twofold greater than the activation with B95.8- or AG876-LMP1
Sylla et al., Proc Natl Acad Sci U S A 1998 : In this report, we show that NF-kappaB activation by LMP1 or by each of its effector sites is mediated by a pathway that includes NIK, IKKalpha, and IKKbeta
Wu et al., Gene Ther 1998 (Nasopharyngeal Neoplasms) : Transcriptional activation of NF-kappa B activity by Epstein-Barr virus ( EBV ) LMP1 as a selective therapeutic strategy for EBV associated diseases
Eliopoulos et al., J Virol 1999 : In addition, the TRAF2 interacting protein A20 blocked both LMP1 induced JNK and NF-kappaB activation, further implicating TRAF2 in these phenomena ... While expression of a kinase-inactive mutated NF-kappaB inducing kinase (NIK) , a mitogen activated protein kinase kinase kinase which also associates with TRAF2, impaired LMP1 signalling on the NF-kappaB axis, it did not inhibit LMP1 induced JNK activation, suggesting that these two pathways may bifurcate at the level of TRAF2