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NEUROD1 — NEUROG1
Text-mined interactions from Literome
Geling et al., Development 2004
:
This involves selective suppression of both neurogenin1 (ngn1) and coe2 mRNA expression in a process that is independent of Notch signalling, and where inhibition of either
ngn1 or coe2 expression is
sufficient to prevent
neuronal differentiation across the midbrain-hindbrain boundary
Kim et al., Cell Mol Neurobiol 2004
:
Neurogenin1 is
sufficient to induce
neuronal differentiation of embryonal carcinoma P19 cells in the absence of retinoic acid
Turnley et al., Pediatr Endocrinol Rev 2005
:
GH and SOCS2 have recently been shown to
regulate neuronal differentiation by controlling expression of a neurogenic transcription factor,
Neurogenin-1
Reyes et al., J Neurosci 2008
(Deafness) :
Transient expression of
Neurog1 promoted widespread
neuronal differentiation in vitro ; when supplemented with brain derived neurotrophic factor (BDNF) and glial cell line derived neurotrophic factor ( GDNF ), 75 % of ES cell derived neurons attained a glutamatergic phenotype after 5 d in vitro
Yan et al., Invest Ophthalmol Vis Sci 2009
:
In low-density cell culture,
ngn1 overexpression
increased neuroD expression and expanded the photoreceptor population but reduced the ganglion population
Quiñones et al., Dev Biol 2010
:
The bHLH transcription factor
Neurog1 ( Ngn1, Neurod3, neurogenin 1 ) is
involved in
neuronal differentiation and cell-type specification in distinct regions of the developing nervous system
Jahan et al., PloS one 2010
:
Neurod1 ,
regulated by both
Neurog1 and Atoh1, could be the mediator of this cross-regulation ... We suggest that
Neurod1 is
regulated by both
Neurog1 and Atoh1 and provides a negative feedback for either gene
Velkey et al., Dev Dyn 2013
:
Results : Transient expression of
Neurog1 in ESC was
sufficient to initiate
neuronal differentiation , and produced neuronal subtypes reflecting its expression pattern in vivo
Olson et al., Mol Cell Neurosci 1998
(Choristoma...) :
GSK3beta, which inhibits NeuroD function in vivo, blocks both Ngn1 induced and NeuroD induced neuronal differentiation, while Notch signaling inhibits only
Ngn1 induced
neuronal differentiation , confirming that NeuroD is downstream of Ngn1 and insensitive to Notch inhibition