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GAS1 — MYC

Text-mined interactions from Literome

Gartel et al., Exp Cell Res 2003 (Cell Transformation, Neoplastic) : Myc suppresses expression of cell cycle/growth arrest genes gas1 , p15, p21, p27, and gadd34, -45, and -153
Lee et al., Proc Natl Acad Sci U S A 1997 : Myc represses transcription of the growth arrest gene gas1 ... We show that c-Myc transcriptionally represses the expression of a growth arrest gene, gas1 ... A conserved Myc structure, Myc box 2, is required for repression of gas1 , and for Myc induction of proliferation and transformation, but not for activation of ODC ... Activation of a Myc-estrogen receptor fusion protein by 4-hydroxytamoxifen was sufficient to repress gas1 gene transcription