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SETD2 — TFRC

Text-mined interactions from Literome

Bianchi et al., Nucleic Acids Res 1999 (Carcinoma, Hepatocellular) : HIF-1 mediated activation of transferrin receptor gene transcription by iron chelation ... The role of HIF-1 in the activation of TfR was indicated by the following observations : ( i ) DFO dependent activation of a luciferase reporter gene in transfected Hep3B cells was mediated by a fragment of the human TfR promoter containing a putative HRE sequence ; ( ii ) mutation of this sequence prevented stimulation of luciferase activity ; ( iii ) binding to this sequence of HIF-1alpha, identified by competition experiments and supershift assays, was induced by DFO ... These results, which show the role of HIF-1 in the control of TfR gene expression in conditions of iron depletion, give insights into the mechanisms of transcriptional regulation which concur with the well characterized post-transcriptional control of TfR expression to expand the extent of response to iron deficiency
Tacchini et al., Hepatology 2002 (Ischemia) : In conclusion, HIF-1 mediated activation of TfR gene transcription and IRP mediated increase of TfR mRNA stability ensure a steady induction of TfR, and hence higher iron uptake in reperfused rat liver
Alberghini et al., J Biol Chem 2005 (Anoxia...) : The loss of VHL strongly up-regulated transferrin receptor expression in RCC10 cells as a result of hypoxia inducible factor-1 (HIF-1) mediated transcriptional activation, leading to an increased uptake of transferrin bound 55Fe
Tacchini et al., J Biol Chem 2008 (Inflammation) : Role of HIF-1 and NF-kappaB transcription factors in the modulation of transferrin receptor by inflammatory and anti-inflammatory signals ... Because TfR1 is up-regulated by the hypoxia-inducible factor ( HIF-1 ), we investigated the effect of inflammatory and anti-inflammatory signals on HIF-1 mediated TfR1 gene expression ... Exposure of mouse macrophages ( RAW 264.7 and J774A.1 cells or peritoneal macrophages ) to LPS/IFNgamma up-regulated NF-kappaB, which in turn rapidly and transiently activated HIF-1 dependent TfR1 expression and iron uptake ... Activation of an anti-inflammatory pathway by pre-exposure to the adenosine A(2A) receptor agonist CGS21680 prevented the inducing effect of LPS/IFNgamma on HIF-1 and TfR1 expression by inhibiting NF-kappaB activity, whereas treatment with CGS21680 alone increased HIF-1 mediated TfR1 expression by means of an NF-kappaB independent signaling pathway
Biswas et al., Biochim Biophys Acta 2013 : These results suggest a novel role of insulin in hepatic iron uptake by a HIF-1 dependent transcriptional regulation of TfR1