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IL6 — PPARG

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IL6 → PPARG (decreases, IL6 Activity)
  Evidence: PPARG ligands have been shown to reduce production of inflammatory cytokines, such as IL-1B, IL-6, inducible nitric oxide synthase and tumor necrosis factor-alpha (TNF-a), by inhibiting the activity of transcription factors such as activator protein- 1 (AP-1), signal transducers and activators of transcription (STAT), and NF-KB in monocytes/macrophages [6, 7].

Text-mined interactions from Literome

Sidell et al., Ann N Y Acad Sci 2002 (Endometriosis) : Our studies include a number of relevant findings : ( 1 ) RU486, acting as an antioxidant, can suppress activation of NFkappaB, a nuclear transcription factor that affects the expression of several inflammatory genes such as those for MCP-1, GM-CSF, CSF-1, and various adhesion molecules ; ( 2 ) IL-6 secretion from a variety of cell types including endometrial cells is inhibited by retinoic acid ; and ( 3 ) retinoids and PPARgamma ligands can upregulate the expression of scavenger receptors in cells of the monocyte/macrophage lineage
Lappas et al., J Clin Endocrinol Metab 2002 : The aim of this study was to elucidate whether natural [ 15-deoxy-Delta ( 12,14 ) -PGJ ( 2 ) ( 15d-PGJ ( 2 ) ) ] and synthetic ( troglitazone ) PPAR-gamma ligands regulate the secretion of IL-6 , IL-8, and TNF-alpha from human intrauterine tissues
Wanichkul et al., Fertil Steril 2003 : To determine whether peroxisome proliferator activated receptor ( PPAR)-gamma ligands can affect the expression of interleukin-6 (IL-6) and cytokines related to the pathogenesis of endometriosis ... In vitro study to determine whether PPARs are expressed in human endometrial cells and determine the effects of various PPAR-gamma ligands on IL-6 and other cytokine expression in these cells
Mrácek et al., Cytokine 2004 : IL-1 and LPS but not IL-6 inhibit differentiation and downregulate PPAR gamma in brown adipocytes
Kim et al., Exp Mol Med 2005 (Arthritis, Rheumatoid) : Other PPARgamma-agonists , such as troglitazone and ciglitazone, did not inhibit IL-6 signaling, indicating that 15d-PGJ ( 2 ) affect the IL-6 induced Jak-Stat signaling pathway via PPARgamma independent mechanism
Peng et al., Hemodial Int 2005 (Kidney Failure, Chronic) : Inhibitory effect of PPAR-gamma activator on IL-6 and mPGES protein expression in PBMC induced by homocysteine ... PPAR-gamma activator could significantly inhibit the increase of IL-6 and mPGES induced by 100 micromol/L HCY ( p < 0.05 and p < 0.01, respectively ) ... In conclusion, HCY can increase the expression of IL-6 and mPGES, while PPAR-gamma activator can inhibit the increase of IL-6 and mPGES induced by HCY
Yu et al., Int J Biochem Cell Biol 2008 : SOCS 3 and PPAR-gamma ligands inhibit the expression of IL-6 and TGF-beta1 by regulating JAK2/STAT3 signaling in pancreas
Garcia-Bates et al., Clin Cancer Res 2008 (Multiple Myeloma) : Additionally, PPARgamma overexpression in multiple myeloma or BMSC inhibited both basal and multiple myeloma induced interleukin-6 production by BMSC
Pitulis et al., Anticancer Res 2009 (Prostatic Neoplasms) : IL-6 induced PPARgamma expression but did not affect the PPARgamma ligand mediated effects on the proliferation of PC-3 cells