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CREB3 — IL6

Text-mined interactions from Literome

Tokunou et al., Arterioscler Thromb Vasc Biol 2001 : Overexpression of the dominant negative form of CREB inhibited thrombin induced IL-6 mRNA expression ... These results suggest that the CRE site and CREB play an important role in thrombin induced IL-6 gene expression in VSMCs. Transactivation of EGF-R and activation of ERK and p38 MAPK are involved in this process
Chen et al., J Biol Chem 2004 (MAP Kinase Signaling System) : Phosphorylation of the transcription factor CREB was also necessary but not sufficient for PTHrP mediated IL-6 promoter activity
Persson et al., Bone 2005 : These observations, together, demonstrate that VIP stimulates IL-6 production in osteoblasts by a mechanism likely to be mediated by VPAC2 receptors and dependent on cyclic AMP/protein kinase A/CREB activation and also involving the transcription factors C/EBP and AP-1
Hannila et al., Exp Neurol 2008 (Spinal Cord Injuries) : It is now known that the effects of cAMP are transcription dependent, and that cAMP mediated activation of CREB leads to upregulated expression of genes such as arginase I and interleukin-6
Shi et al., J Nutr Biochem 2009 : These data suggest that DON induced IL-6 expression is CREB mediated and PKR dependent, and that requisite kinase activities for these pathways were suppressed in macrophages from mice fed DHA for an extended period
Chan et al., J Pharmacol Exp Ther 2009 (Pancreatitis) : cAMP-responsive element binding protein ( CREB ) might be involved in ERK1/2 induced IL-6 expression because phosphorylation of CREB was observed after angiotensin II treatment, which was reversed by losartan and the ERK1/2 inhibitor
Chava et al., Arterioscler Thromb Vasc Biol 2009 (Carotid Artery Injuries...) : CREB mediated IL-6 expression is required for 15 ( S ) -hydroxyeicosatetraenoic acid induced vascular smooth muscle cell migration ... Dominant negative CREB also suppressed balloon injury induced IL-6 expression, SMC migration from media to intimal region, and neointima formation ... The above results suggest a role for 15-LOX2-15-HETE in the regulation of VSMC migration and neointima formation involving CREB mediated IL-6 expression
Allen et al., Am J Physiol Regul Integr Comp Physiol 2010 (Calcium Signaling) : Finally, CREB and C/EBP were necessary for basal IL-6 promoter activity and sufficient to increase IL-6 promoter activity but had minimal roles in calcineurin activated IL-6 promoter activity