Gene interactions and pathways from curated databases and text-mining

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IL3 — JAK2

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Le et al., J Biol Chem 2000 (MAP Kinase Signaling System) : Moreover, the mutations abolished IL-3 induced JAK2 , STAT, and AKT activation in the unselected cells, whereas activation of these molecules in IL-3 selected cells was normal
Yokoyama et al., J Interferon Cytokine Res 2001 : The association between Jak2 and PP2A transiently increases following interleukin-3 (IL-3) stimulation and activation of Jak2
Miura et al., J Immunol 2001 (MAP Kinase Signaling System) : However, only IL-3 and IL-5 induced Janus kinase 2 and STAT5 phosphorylation
Ungureanu et al., Mol Cell Biol 2002 : In unstimulated cells Jak2 was monoubiquitinated, and interleukin-3 or gamma interferon stimulation induced polyubiquitination of Jak2
Yu et al., Oncogene 2003 : Further biochemical analyses revealed that IL-3 induced Jak/Stat , Erk, and PI3 kinase pathways in SHP-2 ( -/- ) cells were impaired and reintroduction of WT SHP-2 into mutant cells partially restored IL-3 signaling
Natarajan et al., Glia 2004 (Encephalitis...) : In this study, we found that in vitro treatment of EOC-20 microglial cells with tyrphostin AG490 blocked IL-3 induced tyrosine phosphorylation of JAK2 , STAT5A, and STAT5B signaling proteins ... Stable transfection of EOC-20 cells with a dominant negative JAK2 mutant also blocked IL-3 induced tyrosine phosphorylation of JAK2 , STAT5A, and STAT5B in microglia
To et al., Br J Cancer 2004 (Cell Transformation, Neoplastic...) : The interleukin mediated Janus kinase ( JAK ) /STAT pathway plays a crucial role in carcinogenesis
Huang et al., J Cell Biochem 2005 : IL-3 induces tyrosine phosphorylation of both JAK1 and JAK2
Pecaric-Petkovic et al., Blood 2009 (Hypersensitivity) : These effects are similar to that of IL-3, but the signaling pathways engaged are distinct because IL-33 strongly activates NF-kappaB and shows a preference for p38 MAP-kinase, while IL-3 acts through Jak/Stat and preferentially activates ERK
Kim et al., Molecular cancer 2010 : In addition, treatment of 32D/IL-2Rbeta cells with the compound led to a block in IL-2 dependent activation of JAK3/STAT5 but not IL-3 dependent activation of JAK2/STAT5
Pradhan et al., J Biol Chem 2010 : In addition, expression of components of the interleukin-3 receptor, IL3Ra and the common beta chain, activated JAK2-V617F as well as STAT5 and ERK
Jatiani et al., Genes & cancer 2010 : ON044580 inhibits mutant JAK2 kinase and the proliferation of JAK2 ( V617F ) -positive leukemic cells and blocks the IL-3 mediated phosphorylation of JAK2 and STAT5
Kandala et al., Drug Discov Ther 2012 (Ovarian Neoplasms) : IL-3 induced phosphorylation of JAK2 and STAT3 was significantly blocked by DIM
Tang et al., Mol Cell Biol 1994 : Conversely, the cytoplasmic kinase JAK2 is activated by IL-3 but not by SCF stimulation
Mui et al., J Leukoc Biol 1995 : Because IL-3 activates JAK2 , we searched for the STAT(s) that might transduce IL-3 signals
Silvennoinen et al., J Immunol 1996 : Finally, CD38 ligation did not inhibit IL-3 induced tyrosine phosphorylation of Jak2
O'Farrell et al., Blood 1996 : IL-3 , but not SCF, leads to activation of Jak 2 and Stat 5 and induces pim-1 expression
Nagata et al., Biochem Biophys Res Commun 1996 : Interleukin 3 activates not only JAK2 and STAT5, but also Tyk2, STAT1, and STAT3 ... It has been described that interleukin 3 (IL3) activates JAK2 , which in turn stimulates STAT5 activation
Kouro et al., Int Immunol 1996 : In the studies described here, we demonstrate that IL-5, IL-3 or GM-CSF stimulation induces the tyrosine phosphorylation of JAK2 , and to a lesser extent JAK1, and of STAT5
Watanabe et al., J Allergy Clin Immunol 1996 : It is well documented that IL-3 or GM-CSF activate JAK2 in BA/F3 cells
Chin et al., Blood 1997 : It was also shown that IL-3 induces rapid and dose dependent association of Jak2 with betaIL3