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EPHB2 — GABBR1
Text-mined interactions from Literome
Tu et al., Cell Signal 2007
:
It has been shown that
GABA(B) receptor activates
ERK ( 1/2 ) in neurons of the central nervous system, but the molecular mechanisms underlying this event are poorly characterized ... Here, we demonstrate that activation of
GABA(B) receptor by either GABA or the selective agonist baclofen
induces ERK ( 1/2 ) phosphorylation in cultured cerebellar granule neurons ... In conclusion, the activation of
GABA(B) receptor leads to
ERK ( 1/2 ) phosphorylation via the coupling of GABA ( B2 ) to G ( i/o ) and by releasing Gbetagamma subunits which in turn induce the activation of CREB
Baloucoune et al., PloS one 2012
(MAP Kinase Signaling System) :
GABAB receptor subunit
GB1 at the cell surface independently
activates ERK1/2 through IGF-1R transactivation ... Furthermore, we demonstrate that
GB1asa induces
ERK1/2 phosphorylation through Gi/o proteins and PLC dependent IGF-1R transactivation