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CREB1 — IL2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Herring et al., Cell Signal 2001
(MAP Kinase Signaling System) :
One of these compounds, cannabinol ( CBN ) has been shown to inhibit
interleukin-2 (IL-2) expression and the
activation of cAMP response element binding protein (
CREB ) and nuclear factor for immunoglobulin kappa chain in B cells ( NF-kappaB ) following phorbol-12-myristate-13 acetate ( PMA ) plus ionomycin ( Io ) treatment of thymocytes
Solomou et al., J Immunol 2001
:
These findings show that
CREB plays a major role in the transcriptional regulation of
IL-2 and that a major pathway for the activation of CREB and its subsequent binding to the IL-2 promoter/enhancer in normal T cells is mediated by PKC-theta
Thomas et al., Arch Toxicol 2005
:
In this study we address the
effects of
IL-2 and IL-12 on the TBT induced decreases in NK-cell levels of the cytotoxic proteins, their mRNAs, and
CREB phosphorylation
Bostik et al., J Immunol 2007
(Disease Susceptibility...) :
CD4+ T cells from simian immunodeficiency virus disease-resistant sooty mangabeys produce more IL-2 than cells from disease-susceptible species :
involvement of p300 and
CREB at the proximal IL-2 promoter in
IL-2 up-regulation
Kaiser et al., Eur J Immunol 2007
:
This correlated to a reduction in the TCR induced up-regulation of the IL-2 receptor CD25 and a requirement for MSK in
IL-2 induced
CREB phosphorylation
Feuerstein et al., J Immunol 1995
:
By using specific Abs in a gel mobility shift assay, we identified two known CREB/ATF transcription factors in the
IL-2 induced CRE complexes : the
CRE binding factor ( CREB ) , and ATF1 ... The
induction of
CREB binding by
IL-2 was not associated with an increase in its abundance but was associated with a major increase in CREB phosphorylation that was particularly prominent at late G1/S
Good et al., EMBO J 1996
:
In the present study, we demonstrate that neither NF-kappa B/Rel nor
CREB/ATF is
sufficient for Tax mediated activation of the
IL-2 promoter
Guyot et al., Immunol Lett 1998
:
However, while neither
IL-2 nor CD3 cross linking alone
induced P-CREB , a 4.5-fold increase in phosphorylation of CREB within 1 h of IL-2/CD3 co-stimulation was observed
Belkowski et al., J Immunol 1998
:
These results indicate that
IL-2 induces a rapamycin-sensitive, cAMP independent
CREB kinase activity in L2 cells