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CDK4 — CDKN2D

Pathways - manually collected, often from reviews:

• KEGG Cell cycle: CDKN2D → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• Reactome Reaction: CDK4 → CDKN2D (direct_complex) Guan et al., Genes Dev 1994*, Hannon et al., Nature 1994*, Serrano et al., Nature 1993, Guan et al., Mol Biol Cell 1996*
• Reactome Reaction: CDK4 → CDKN2D (reaction) Guan et al., Genes Dev 1994*, Hannon et al., Nature 1994*, Serrano et al., Nature 1993, Guan et al., Mol Biol Cell 1996*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CDKN2D — CDK4 (physical association, affinity chromatography technology) Waaijers et al., J Proteome Res 2013
• IRef Biogrid Interaction: CDKN2D — CDK4 (physical association, affinity chromatography technology) Varjosalo et al., Nat Methods 2013
• IRef Biogrid Interaction: CDKN2D — CDK4 (direct interaction, two hybrid) Rual et al., Nature 2005
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Hirai et al., Mol Cell Biol 1995*
• IRef Hprd Interaction: CDKN2D — CDK4 (in vivo) Chan et al., Mol Cell Biol 1995*
• IRef Hprd Interaction: CDKN2D — CDK4 (in vitro) Chan et al., Mol Cell Biol 1995*
• IRef Hprd Interaction: Complex of CDK4-CCND1-CDKN2D-CCND1-CDK4-CDKN2D-CDKN2D-CDK4-CCND1 (in vivo) Hirai et al., Mol Cell Biol 1995*
• IRef Intact Interaction: CDKN2D — CDK4 (physical association, two hybrid pooling approach) Rual et al., Nature 2005
• IRef Intact Interaction: Complex of CDKN1B-CDKN2D-CDK13-CDKN2A-CDKN2C-CDKN2B-CDK4 (association, tandem affinity purification) Varjosalo et al., Cell reports 2013
• IRef Ophid Interaction: CDKN2D — CDK4 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Bartkova et al., Oncogene 2000 (Germinoma...) : p19INK4d , a member of the INK4 family of cyclin dependent kinase inhibitors, negatively regulates the proto-oncogenic cyclin D/CDK4 ( 6 ) complexes whose ability to phosphorylate the retinoblastoma tumour suppressor ( RB ) promotes G1/S transition
Lin et al., PloS one 2013 : Quantitative real-time PCR and Western blot analyses showed that PTB overexpression in H1299 cells specifically induced the expression of p19(Ink4d) , an inhibitor of cyclin dependent kinase 4