Gene interactions and pathways from curated databases and text-mining

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MAPK3 — REN

Text-mined interactions from Literome

Huang et al., Kidney Int 2007 : We tested the hypothesis that renin receptor activation, in turn, activates the extracellular-signal regulated kinase 1 and 2 ( ERK1/2 ) of the mitogen activated protein kinase system in mesangial cells
Feldt et al., J Am Soc Nephrol 2008 (Hypertension) : Preincubation with the HRP or aliskiren did not prevent renin- and prorenin induced extracellular signal regulated kinase 1/2 phosphorylation, whereas the MAP kinase kinase (MEK1/2) inhibitor PD98059 prevented both
Feldman et al., Hypertension 2008 (Albuminuria...) : In human mesangial cells, aliskiren ( 0.1 micromol/L to 10 micromol/L ) did not inhibit binding of ( 125 ) I-renin to the ( pro ) renin receptor, nor did it alter the activation of extracellular signal regulated kinase 1/2 by renin ( 20 nmol/L ) preincubated with aliskiren ( 100 nmol/L ) or affect gene expression of the ( pro ) renin receptor
Advani et al., Hypertension 2009 (Disease Models, Animal) : In collecting duct/distal tubule lineage Madin-Darby canine kidney cells, extracellular signal regulated kinase 1/2 phosphorylation, induced by either renin or prorenin, was attenuated by the selective vacuolar H ( + ) -ATPase inhibitor bafilomycin