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IL8 — SYT1
Text-mined interactions from Literome
Wang et al., Zhonghua Gan Zang Bing Za Zhi 2011
(Carcinoma, Hepatocellular...) :
p38 MAPK inhibitor ( SB203580 ) could significantly inhibit
IL-8 production in a dose dependent manners ( F = 65.47, P < 0.01 ), and partially
inhibited NF-kB
p65 nuclear translocation in a dose dependent manner ( F=141.20, P < 0.05 )
Ember et al., J Gen Virol 2012
(Poxviridae Infections...) :
Consistent with this, C4 inhibited
interleukin-1ß induced translocation of
p65 into the nucleus
Byun et al., Biochem Biophys Res Commun 2012
(Inflammation) :
In addition, EGCG treated DCs inhibited lipopolysaccharide (LPS) induced production of pro-inflammatory cytokines ( tumor necrosis factor [TNF ] -a,
interleukin [ IL]-1ß, and IL-6 ) and
activation of mitogen activated protein kinases ( MAPKs ), e.g., extracellular signal regulated kinase 1/2 ( ERK1/2 ), p38, c-Jun N-terminal kinase (JNK), and nuclear factor ?B ( NF-?B )
p65 translocation through 67LR
Takeuchi et al., PLoS Pathog 2013
:
NF-?B is a transcriptional regulator that controls important aspects of innate immune responses, and NF-?B
RelA/p65 homodimers
regulate transcription of
IL8
Kunsch et al., J Immunol 1994
:
Synergistic transcriptional
activation of the
IL-8 gene by NF-kappa B
p65 ( RelA ) and NF-IL-6
Harant et al., Eur J Biochem 1997
:
Furthermore, overexpression of VDR in the parental G-361 cell line enhanced the repressive effect of calcitriol on
activation of the
IL-8 promoter by either TNF-alpha stimulation or overexpression of the NF-kappaB subunit
p65