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IFNB1 — RELA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Algarté et al., J Virol 1999
(Respirovirus Infections) :
These experiments demonstrate a major role for IkappaBalpha in the regulation of
NF-kappaB induced
IFN-beta gene activation and a minor role for IkappaBbeta in the activation process
Fang et al., J Neurovirol 2001
:
Induction of
IFN-beta and MHC class I gene expression
requires NF-kappaB activation which depends on degradation of IkappaBalpha, an inhibitory protein of NF-kappaB
Escalante et al., Structure 2002
:
Upon viral infection,
NF-kappaB translocates to the nucleus and
activates the
IFN-beta gene by binding to the PRDII element
Kim et al., J Neurochem 2002
:
IFNbeta induced IkappaBalpha degradation and
NF-kappaB ( p65 : p50 ) DNA binding
Rani et al., J Biol Chem 2002
(Fibrosarcoma) :
IFN-beta treatment did not
augment the abundance of
NF-kappa B , but led to phosphorylation of the NF-kappa B subunit p65 and induced a nuclear activity capable of phosphorylating a p65-GST fusion construct in the carboxy-terminal transactivation domain ( TAD ), residues 354-551
Yamamoto et al., J Immunol 2002
:
Dominant negative TRIF inhibited TLR3 dependent activation of both the
NF-kappaB dependent and
IFN-beta promoters
Thanos et al., Cell 1992
(Tumor Virus Infections) :
In this paper, we show that both
NF-kappa B and the high mobility group protein I ( Y ) ( HMG I(Y) ) are
required for virus induction of the human
interferon-beta (IFN-beta) gene
Bose et al., J Interferon Cytokine Res 2003
(Paramyxoviridae Infections) :
The antiviral cytokine
IFN-alpha/beta ( IFN type I ) produced following viral infection as a
result of activation of
NF-kappaB or IRF-3 or both exerts an antiviral state by inducing the Janus kinases/signal transducer and activator ( Jak-Stat ) pathway
van Holten et al., Arthritis Res Ther 2004
(Arthritis, Experimental...) :
We also examined the
effect of
IFN-beta on
NF-kappaB activity
Harii et al., Mol Endocrinol 2005
(Thyroiditis, Autoimmune...) :
In this report, we demonstrate TLR3 mRNA and protein are expressed on Fisher rat thyroid cell line-5 ( FRTL-5 ) thyroid cells and are functional because incubating cells with polyinosine-polycytidylic acid causes 1 ) transcriptional
activation of both the nuclear factor kappaB (NF-kappaB)/Elk1 and interferon (IFN) regulatory
factor-3/IFN-beta signal paths, 2 ) posttranscriptional activation of
NF-kappaB and ERK1/2, and 3 ) increased IFN-beta mRNA
Aksoy et al., Eur J Immunol 2005
:
Experiments carried out in HEK 293T cells stably expressing TLR3 or TLR4 confirmed that inhibition of PI3K activity enhances
NF-kappaB dependent promoters as well as
IFN-beta promoter activities without interfering with transcription at the positive regulatory domain III-I
O'Donnell et al., J Clin Invest 2005
(Myocarditis...) :
Treatment of p50-null mice with IFN-beta substantially diminished reovirus replication and apoptosis, which suggests that
IFN-beta induction by
NF-kappaB protects against reovirus induced myocarditis
Seth et al., Cell 2005
(Respirovirus Infections) :
Conversely, overexpression of MAVS
induces the expression of
IFN-beta through activation of
NF-kappaB and IRF 3, thus boosting antiviral immunity
Chang et al., Microbes Infect 2006
:
NF-kappaB activation is
essential for
IFN-beta induction in JEV- and DEN-2 infected cells
Iversen et al., J Immunol 2005
:
Activated NK cells expressed lymphotoxin ( LT ) alphabeta on their cell surface, and secreted LTalpha and TNF, all of which contributed to the
NF-kappaB dependent release of
IFN-beta from infected fibroblasts
Liu et al., J Virol 2007
:
In contrast, siRNA mediated TLR3 knockdown did not affect RSV induced
NF-kappaB binding but did
inhibit IFN-beta , IP-10, CCL-5, and ISG15 expression at late times of infection
Ock et al., J Neurosci Res 2007
(Inflammation) :
Hypoxia, however, differentially regulated MyD88 dependent and -independent pathways of TLR4 signaling : Hypoxia
enhanced lipopolysaccharide (LPS) induced interferon regulatory factor-3 (IRF-3) activation and the subsequent expression of
IFNbeta ( MyD88 independent pathway ), whereas it suppressed LPS induced
NF-kappaB activation ( MyD88 dependent pathway )
Suh et al., J Virol 2007
(Cytomegalovirus Infections...) :
PIC induction of IDO was mediated in part by
IFN-beta but not IFN-gamma, and both
NF-kappaB and interferon regulatory factor 3 (IRF3) were
required
Lefort et al., J Virol 2007
:
Of interest,
ifn-beta gene activation by K-bZIP is
independent of interferon ( IFN ) -responsive factor 3 ( IRF-3 ) and
nuclear factor kappaB (NF-kappaB) activation
Rui et al., J Immunol 2007
:
In this study, we demonstrate that PECAM-1 ligation with CD38-Fc fusion protein negatively
regulates LPS induced proinflammatory cytokine TNF-alpha, IL-6, and
IFN-beta production by inhibiting JNK,
NF-kappaB , and IFN regulatory factor 3 activation in macrophages
Kotla et al., Virology 2008
:
The type I interferon ( IFN ) response requires the coordinated activation of the latent transcription factors
NF-kappaB , IRF-3 and ATF-2 which in turn
activate transcription from the
IFN-beta promoter
Alff et al., J Virol 2008
:
The formation of TBK1-TRAF3 complexes directs IRF-3 phosphorylation, and both IRF-3 and
NF-kappaB activation are
required for transcription from the
IFN-beta promoter
Kaiser et al., J Immunol 2008
:
Suppression of RIP1 expression by RNAi abrogates
NF-kappaB activation as well as
IFNbeta induction by immunostimulatory DNA
Li et al., Biochem Biophys Res Commun 2009
(Herpes Genitalis) :
More importantly, our data provide direct evidence that the activation of
NF-kappaB is
required for the production of both IL-6 and
IFN-beta induced by HSV-2 in HCE cells
Wu et al., Hepatology 2009
:
Pretreatment of hepatocytes and NPCs with HBV-Met cells supernatants, HBsAg, HBeAg, or HBV virions almost completely abrogated TLR induced antiviral activity, which correlated with suppression of
interferon beta (IFN-beta) production and subsequent interferon stimulated gene induction as well as suppressed
activation of interferon regulatory factor 3 (IRF-3),
nuclear factor kappa B (NF-kappaB) , and extracellular signal regulated kinase ( ERK ) 1/2
Myskiw et al., J Virol 2009
:
IL-6 induction is regulated by NF-kappaB, while
IFN-beta induction is
mediated by IFN-beta promoter stimulator 1 and IFN regulatory factor
3/NF-kappaB
Daffis et al., PLoS Pathog 2009
(West Nile Fever) :
However, pharmacological inhibition of
NF-kappaB and ATF-2/c-Jun, the two other known components of the IFN-beta enhanceosome, strongly
reduced IFN-beta gene transcription in the DKO dendritic cells
Mao et al., J Biol Chem 2010
:
Here we show that knockdown of the E3 ubiquitin ligases cIAP1 and cIAP2 markedly inhibited virus triggered activation of IRF3 and
NF-kappaB as well as
IFN-beta induction
Li et al., J Virol 2010
:
However, knockdown of RIG-I only partially blocked NF-kappaB activity induced by MHV infection and inhibition of
NF-kappaB activity by a decoy peptide inhibitor
had little effect on
IFN-alpha/beta production
Zheng et al., J Immunol 2010
:
In addition to promoting both MyD88- and TLR/IL-1 receptor domain containing adaptor protein inducing
IFN-beta dependent MAPKs and
NF-kappaB activation, Gab1 enhances PI3K/Akt activation by directly binding p85 in TLR signaling and VSV infection
Dhib-Jalbut et al., J Immunol 1995
:
Induction of
IFN-beta gene expression by virus
requires binding of
NF-kappa B to the positive regulatory domain II element of the IFN-beta promoter