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BCL2 — CXCL12

Text-mined interactions from Literome

Karl et al., Cancer Res 2005 (Corneal Neovascularization) : Inhibition of Bcl-2 expression with small interfering RNA-Bcl-2, or the inhibition of Bcl-2 function with small molecule inhibitor BL-193, down-regulated CXCL8 and CXCL1 expression and caused marked decrease in the angiogenic potential of endothelial cells without affecting cell viability
Hernández-López et al., Immunol Lett 2008 : The survival promoting effect of CXCL12 was mediated by the up-regulation of Bcl-2 protein expression and the concomitant down-regulation of Bax protein expression
Neiva et al., Neoplasia (New York, N.Y.) 2009 (Carcinoma, Squamous Cell) : Here, we observed that Bcl-2 signaling induces expression of IL-6, CXCL8 , and EGF, providing a mechanism for the upregulation of these cytokines in tumor associated endothelial cells