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AKT1 — RAC1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Genot et al., Mol Cell Biol 2000
:
We show that in Jurkat cells, activated forms of
Rac1 or Cdc42, but not Rho,
stimulate an increase in
Akt/PKB activity ... Similar to TCR stimulation,
L61Rac induced
Akt/PKB kinase activity is also LY294002 and wortmannin sensitive ... Similar to TCR stimulation,
L61Rac induced
Akt/PKB kinase activity is also LY294002 and wortmannin sensitive
Djouder et al., J Immunol 2001
(Calcium Signaling) :
Rac and phosphatidylinositol 3-kinase
regulate the
protein kinase B in Fc epsilon RI signaling in RBL 2H3 mast cells ... Our results indicate that in rat basophilic leukemia cells
Rac and PI3-kinase
regulate PKB and suggest that Rac is functionally located upstream and/or parallel of PI3-kinase/PKB in FcepsilonRI signaling
Sánchez-Martín et al., J Biol Chem 2004
:
We have identified Vav, a guanine nucleotide exchange factor for Rac-1, and PI3K/Akt, as regulators of the activation and inactivation phases of the activity of Rac-1, respectively, in the context of LFA-1 signaling based on the following experimental evidence : ( i ) LFA-1 induced activation of Vav and
PI3K/Akt with kinetics consistent with a regulatory role for these molecules on Rac-1, ( ii ) overexpression of a constitutively active Vav mutant induces activation of Rac independently of LFA-1 stimulation whereas overexpression of a dominant negative Vav mutant
blocks LFA-1 mediated
Rac activation, ( iii ) pharmacological inhibition of PI3K/Akt prevented the fall in the activity of Rac-1 after its initial activation but had no effect on Vav activity, and ( iv ) overexpression of a dominant negative or a constitutively active Akt-1 induced or inhibited, respectively, Rac-1 activity
Fukuyama et al., Biochem Biophys Res Commun 2004
:
Dominant negative
Rac severely inhibited PDGF induced osteoblast migration and
reduced Akt phosphorylation
Gakidis et al., J Cell Biol 2004
:
beta2 induced activation of Cdc42,
Rac1 , and RhoA is defective in Vav1/3ko neutrophils, and phosphorylation of Pyk2, paxillin, and
Akt is also significantly
reduced
Goparaju et al., Mol Cell Biol 2005
:
Although S1P(2) deletion had no significant effect on tyrosine phosphorylation of the PDGF receptors or activation of extracellular signal regulated kinase 1/2 or
Akt induced by PDGF, it reduced sustained PDGF dependent p38 phosphorylation and markedly
enhanced Rac activation
Fukuda et al., J Bone Miner Res 2005
(Bone Resorption) :
Rac1 ( DN ) also partially
blocked the activation of
Akt induced by the overexpressing catalytic subunit of PI3K
Gonzalez et al., J Biol Chem 2006
:
Taken together, these studies identify G protein betagamma subunits, Src kinase and the GEF Tiam1 as upstream modulators of S1P mediated Rac1 activation, and establish a central
role for
Rac1 in S1P mediated activation of PI
3-kinase/Akt/endothelial nitric-oxide synthase signaling in vascular endothelial cells
Lee et al., Histochem Cell Biol 2006
:
In this report, we describe that S1P stimulated cortactin translocation to the cell periphery to form lamellipodia is specifically mediated by the endothelial S1P1 G-protein coupled receptor, and is regulated by G ( i ) -mediated
Akt dependent S1P1 receptor phosphorylation and
Cdc42/Rac activation pathways
Jin et al., Am J Physiol Gastrointest Liver Physiol 2006
(MAP Kinase Signaling System) :
However, inhibition of
Rac1 significantly decreased apoptosis in the
presence of ERK1/2 and
Akt inhibitors, similar to the effect observed with NSC-23766 alone in response to TNF-alpha
Morley et al., Cell Signal 2007
(Cell Transformation, Neoplastic) :
We found that Dbl
induced the phosphorylation of
Akt on threonine 308, through the GTPases
Rac and Cdc42 and in a PI3-kinase dependent manner
Zhang et al., Neuroscience 2006
(Disease Models, Animal...) :
Co-immunoprecipitation analysis reveals that Akt physically interacts with Rac1, a small Rho family GTPase required for mixed lineage kinase 3 (MLK3) autophosphorylation, and both this interaction and
Rac1-Ser-71 phosphorylation
induced by
Akt are promoted in preconditioned rats
Zhou et al., J Biol Chem 2006
:
Opposing
roles for
Akt1 and Akt2 in
Rac/Pak signaling and cell migration
JeBailey et al., Diabetes 2007
(Insulin Resistance) :
Small interfering RNA dependent Rac1 knockdown prevented actin remodeling and GLUT4 translocation but spared Akt phosphorylation, suggesting that
Rac and actin remodeling do not
contribute to overall
Akt activation
Jin et al., Neurochem Int 2007
:
These results suggest that the NGF induced ruffling requires activation of
Rac1 and Cdc42, but does not
require Ras, PI-3k,
Akt and GSK-3beta
Chaigne-Delalande et al., Oncogene 2008
:
Constitutively active
Rac stimulates
Akt activity in T lymphocytes cultured in suspension ... We now show that
V12Rac mediated stimulation of
Akt is not restricted to the hematopoietic lineage but is dependent on the adherence status of the cell ...
V12Rac mediated stimulation of
Akt as well as molecular association between Rac and Akt occurred exclusively in cells kept in suspension
Tan et al., Biochim Biophys Acta 2008
(Carcinoma, Hepatocellular...) :
The
Rac1 activation by HBV replication also
resulted in the phosphorylation of ERK1/2 and
AKT , the downstream targets of Rac1 signaling cascade
Muñoz-Alonso et al., J Pharmacol Exp Ther 2008
(Melanoma) :
By using inhibitors, we found that JNK and p38 MAPK activation depends on Rac1 but not on phosphatidylinositol 3-kinase (PI3K), whereas
AKT activation is
independent of
Rac1 but requires PI3K activity
Kuijk et al., Blood 2008
(Mevalonate Kinase Deficiency) :
The small GTPase
Rac1 was activated by simvastatin, and this was
required for both
PKB activation and IL-1beta secretion
Somanath et al., J Cell Physiol 2009
:
While activation of
Akt1 resulted in translocation of
Rac1 to membrane ruffles, enhanced Rac1 activity, Pak1 phosphorylation, and lamellipodia formation, resulting in enhanced adhesion and assembly of fibronectin, inhibition of Akt1 resulted in inhibition of these processes due to impaired Rac1-Pak signaling
Nie et al., Cell Signal 2010
:
Heterologous expression of P-Rex1 in COS ( phox ) cells potentiated fMet-Leu-Phe induced Akt phosphorylation, whereas expression of a constitutively active form of
Akt enhanced
Rac1 activation ... In contrast, a dominant negative
Akt mutant
reduced the fMet-Leu-Phe stimulated superoxide generation as well as
Rac1 activation
Venkatesan et al., J Mol Cell Cardiol 2010
:
EMMPRIN activates multiple transcription factors in cardiomyocytes, and induces interleukin-18 expression via
Rac1 dependent
PI3K/Akt/IKK/NF-kappaB andMKK7/JNK/AP-1 signaling ... We show for the first time that EMMPRIN stimulates the activation of NF-kappaB, AP-1, CREB, and ATF-2 in cardiomyocytes, and induces IL-18 expression via
Rac1 dependent
PI3K/Akt/IKK/NF-kappaB and MKK7/JNK/AP-1 signaling
Song et al., Journal of neuroinflammation 2012
(Neuroblastoma) :
We also found that
Src/PI3K/Akt inhibitors prevented LLLT stimulated Akt ( Ser473 and Thr308 ) phosphorylation and
blocked Rac1 activity and actin based microglial phagocytosis, indicating the activation of Src/PI3K/Akt/Rac1 signaling pathway
Nozaki et al., Cell Signal 2013
:
Here, we investigate the
role of
Akt in the regulation of
Rac1 in myocytes
Yang et al., Journal of biomedical research 2011
:
Furthermore, expression of dominant negative
Rac1 ( T17N ) could largely
block EGF induced
PI3K/Akt-PAK1 activation and cell migration
Miranti et al., Curr Biol 1998
:
This pathway may regulate multiple downstream events in hematopoietic cells, including
Rac induced lamellipodia formation, tyrosine phosphorylation of Cbl, and activation of JNK, ERK2 and the phosphatidylinositol 3'-kinase regulated kinase
Akt
Nishida et al., Oncogene 1999
:
Furthermore, the serine/threonine kinase
Akt was
stimulated by activated
Rac and fetal bovine serum in a synergistic manner