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BCL10 — FGF2
Text-mined interactions from Literome
Bryckaert et al., Oncogene 1999
:
FGF2 also
increased the de novo synthesis and the production of
Bcl-xl before the onset of apoptosis ... Both inhibition of ERK2 activation, which decreased Bcl-xl synthesis, and downregulation of
Bcl-x by antisense oligonucleotide treatment
inhibited the survival promoting activity of
FGF2
Cuevas et al., Neurol Res 2000
(Carotid Artery Injuries) :
In addition,
FGF-1 treatment also
induces expression of the
bcl-X anti-apoptotic protein in the same site of the media showing VSMC apoptosis
Désiré et al., J Neurochem 2000
:
Exogenous
FGF2 supported neuronal survival after serum deprivation and
increased neuronal
bcl-x ( L ) and bcl-2 expression, through binding to its receptor R1 ( FGF-R1 ), and subsequent extracellular signal regulated kinase ( ERK ) activation ... Indeed, long-term ERK activation and high
bcl-x ( L ) levels are
necessary for the survival activity of both exogenous and endogenous
FGF2
Mascarelli et al., J Soc Biol 2001
(MAP Kinase Signaling System...) :
FGF2 induces long-term activation of FGFR1 and ERK1/2, and production of the anti-apoptotic protein
BcL-x
Pardo et al., J Biol Chem 2002
:
Fibroblast growth factor-2 induces translational regulation of
Bcl-XL and Bcl-2 via a MEK dependent pathway : correlation with resistance to etoposide induced apoptosis
Kim et al., BMB Rep 2012
:
Chemical inhibition of FGFR, NFkB, and PI3K activity by PD173074, pyrrolidine dithiocarbamate, and LY294002 respectively abrogated the
FGF-2 mediated induction of Bcl2-A1 and
Bcl-xL expression