Gene interactions and pathways from curated databases and text-mining

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CREB3 — GSK3B

Pathways - manually collected, often from reviews:

  • KEGG Prostate cancer: GSK3B → ATF4/CREB1/CREB3/CREB3L1/CREB3L2/CREB3L3/CREB3L4/CREB5 (protein-protein, inhibition)

Text-mined interactions from Literome

Grimes et al., J Neurochem 2001 : CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium ... Inhibition of GSK3 beta by another paradigm, treatment with the selective inhibitor lithium, also increased CREB DNA binding activity ... The inhibitory regulation of CREB DNA binding activity by GSK3 beta also was evident in differentiated SH-SY5Y cells, indicating that this regulatory interaction is maintained in non proliferating cells ... These results demonstrate that inhibition of GSK3 beta by serine-9 phosphorylation or directly by lithium increases CREB activation ... Conversely, overexpression of active GSK3 beta to 3.5-fold the normal levels completely blocked increases in CREB DNA binding activity induced by epidermal growth factor, insulin-like growth factor-1, forskolin, and cyclic AMP
Mai et al., J Neurochem 2002 (Neuroblastoma) : Therefore, increased GSK3beta selectively attenuates BDNF induced CREB phosphorylation, and lithium and carbamazepine can facilitate activation of CREB
Hansen et al., Neuroreport 2004 (Neuroblastoma) : We conclude that GSK-3beta regulates cAMP induced CCK transcription by reducing CREB binding to the CRE ( -80 ) element in the CCK promoter
Singh et al., International journal of biological sciences 2007 : Suppression of GSK-3beta by SB216763 ( 100 nM ) increases CREB phosphorylation, cyclin D1 and fibronectin levels
Xia et al., Neuropharmacology 2010 (MAP Kinase Signaling System) : Finally, either BDNF or GSK-3beta inhibition prevented PCP induced suppression of cyclic-AMP response element binding protein ( CREB ) phosphorylation ... These data demonstrate that the protective effect of BDNF against PCP induced apoptosis is mediated by parallel activation of the PI-3K/Akt and ERK pathways, most likely involves inhibition of GSK-3beta and activation of CREB