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IL10 — IRF4

Text-mined interactions from Literome

Lee et al., Mol Immunol 2009 : A distal cis-regulatory element, CNS-9, controls NFAT1 and IRF4 mediated IL-10 gene activation in T helper cells ... Collectively, our results establish crucial roles for enhancer element CNS-9, and NFAT1 and IRF4 that bind to it, for IL-10 expression in differential T helper subsets
Ahyi et al., J Immunol 2009 : IRF4 interacts with PU.1, and in PU.1-deficient T cells there was an increase in IRF4 binding to the Il10 gene, and in the ability of IRF4 to induce IL-10 production compared with wild-type cells and Il10 promoter activity in a reporter assay
Li et al., Nature 2012 : Moreover, we show that AP1 and IRF complexes cooperatively promote transcription of the Il10 gene, which is expressed in T ( H ) 17 cells and potently regulated by IL-21