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BCL2 — CD28

Text-mined interactions from Literome

Khoshnan et al., J Immunol 2000 : Taken together, these data demonstrate that CD3/CD28 induced activation of IKK beta and expression of Bcl-xL promote the survival of primary human CD4+ T lymphocytes
McKean et al., J Immunol 2001 (MAP Kinase Signaling System) : Importantly, when TCR activated thymocytes are simultaneously coengaged by both CD28 and CD2 receptors, CD28 signals can inhibit ERK/MAPK dependent Bcl-2 protein up-regulation
Kosmaczewska et al., Arch Immunol Ther Exp (Warsz) 2001 : The interaction between the costimulatory molecule CD28 on T cells and members of the B7 family on antigen presenting cell results in upregulation of T cell proliferation and cytokine production and induces the expression of the anti-apoptotic protein Bcl-xl
Tamma et al., J Leukoc Biol 2006 (MAP Kinase Signaling System) : In the present study, we showed that stimulation of normal CD4+ T cells with jacalin plus CD28 cross linking ( CD28XL ) resulted in phosphorylation of signal transducer and activator of transcription ( STAT ) -6 and expression of Bcl-2 and Bcl-xL , which were inhibited significantly when cells were cultured in the presence of the p38 mitogen activated protein kinase ( MAPK ) inhibitor SB203580
Yang et al., Nan Fang Yi Ke Da Xue Xue Bao 2007 : [ Regulation of Bcl-2 expression in ageing T cells by CD137 and CD28 ]
Boise et al., Curr Opin Immunol 1995 : CD28 not only enhances IL-2 production, which can act as an extrinsic regulator of cell survival, but also augments the expression of the intrinsic survival factor Bcl-xL
Lin et al., J Immunol 1997 : Furthermore, CD28 costimulation can prevent anti-TNFR2 induced apoptosis and restore Bcl-xL expression
Collette et al., Blood 1998 : Conversely, CD28 mediated signals increase expression of Bcl-XL , a survival gene, and promote survival of naive T cells cultured in the absence of antigen or costimulation