Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

PĂ©rez et al., Diabetes 2004 : However, at elevated concentrations, leptin impaired insulin stimulated MAPK activity, glycogen synthase kinase (GSK)3beta phosphorylation, and insulin receptor tyrosine phosphorylation without altering vanadate stimulation
Paulus et al., Neuropsychobiology 2005 : Central nervous effects of leptin and insulin on hippocampal leptin and insulin receptor expression following a learning task in Wistar rats
Eguchi et al., Mol Cell Endocrinol 2007 : In summary, leptin induced SOCS-3 expression and its association with the insulin receptor in rat skeletal muscle cells but functional significance of this increase was not apparent upon measuring glucose uptake
Srivastava et al., Reproduction 2007 (Anovulation) : The in vitro study confirmed the in vivo observations of inhibitory effect of leptin on LH induced StAR expression and E2 production, whereas the stimulatory effect of leptin ( high dose ) on LH induced expression of insulin receptor protein and A4 production
Nazarians-Armavil et al., Mol Endocrinol 2013 : Neuronal insulin resistance, as assessed by attenuated Akt phosphorylation, blocked leptin mediated signal transduction and agouti related peptide, urocortin-2, IRS1, IRS2, and insulin receptor synthesis
Nowak et al., Life Sci 1998 : Acute leptin action on insulin blood level and liver insulin receptor in the rat