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IL8 — SAA1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Furlaneto et al., Biochem Biophys Res Commun 2000
:
This study focuses on the
effect of AI,
SAA , and HDL from healthy ( N-HDL ) and acute phase individuals ( AP-HDL ) on the release of TNF-alpha, IL-1beta, and
IL-8 by human blood neutrophils
Sasaki et al., J Med Microbiol 2001
(Streptococcal Infections) :
Furthermore, a reverse transcription-PCR assay revealed that
SAA 10 microg/ml could
induce mRNA accumulation of tumour necrosis factor-alpha,
interleukin (IL)-1beta and IL-6 as well as iNOS
Ribeiro et al., Mediators Inflamm 2003
:
In a previous study, we reported that
SAA induces the release of tumor necrosis factor-alpha,
interleukin (IL)-1beta and IL-8 from human blood neutrophils ... Here, we extend our earlier study, focusing on the
effect of
SAA on neutrophil
IL-8 transcription and on the signaling pathways involved ... We demonstrate herein that
SAA , in relatively low concentrations ( 0.4-100 microg/ml ) compared with those found in plasma in inflammatory conditions,
induces a dose dependent release of
IL-8 from neutrophils ...
SAA also
induces IL-8 expression and release from monocytes
Hatanaka et al., Immunol Lett 2004
:
Recently, we described the
effect of the acute phase protein
serum amyloid A (SAA) on the mRNA expression and release of
IL-8 in neutrophils [ Mediators Inflamm. 12 ( 3 ) ( 2003 ) 173 ]
Thorn et al., Scand J Immunol 2004
:
Here, we examine the
roles of TNF-alpha,
interleukin-6 (IL-6) and GCs on the transcriptional regulation of the two human
A-SAA genes ( SAA1 and SAA2 ) and show that these stimuli have different effects on the SAA1 and SAA2 promoters in HepG2 hepatoma and KB epithelial cell lines
Sodin-Semrl et al., Int J Immunopathol Pharmacol 2004
(Arthritis, Rheumatoid) :
Opposing
regulation of
interleukin-8 and NF-kappaB responses by lipoxin A4 and
serum amyloid A via the common lipoxin A receptor
Baranova et al., J Biol Chem 2005
(MAP Kinase Signaling System) :
The levels of the
SAA induced
interleukin-8 (IL-8) secretion by CLA-1 overexpressing cells also significantly exceeded ( 5- to 10-fold ) those detected for control cells ... Synthetic amphipathic peptides possessing a structural alpha-helical motif inhibited
SAA induced activation of both MAPKs and
IL-8 secretion in THP-1 cells
Jijon et al., Eur J Immunol 2005
:
Further, Ad5IkappaBAA abrogated
SAA induced RelA nuclear translocation, NF-kappaB transcriptional activity and
IL-8 gene expression ...
SAA dependent
IL-8 gene expression required activation of the MAPK ERK, p38 and JNK in HT-29 cells
Sandri et al., Immunol Lett 2008
:
In previous studies, we demonstrated that
SAA stimulated the production of TNF-alpha, IL-1beta,
IL-8 , NO, and ROS by neutrophils and/or mononuclear cells
Lee et al., Exp Mol Med 2009
:
Among the ligands tested, LL-37 was found to specifically inhibit
SAA induced
IL-8 production in transcriptional and post-transcriptional levels ... Since
SAA stimulated
IL-8 production via ERK and p38 MAPK in human neutrophils, we tested the effect of LL-37 on SAA induction for these two MAPKs
Mullan et al., Am J Pathol 2010
(Arthritis, Rheumatoid...) :
A-SAA induced
interleukin-6 and -8 production was inhibited in the presence of anti-SR-B1 in human microvascular endothelial cells and RA FLCs
Rienhoff et al., Mol Biol Med 1990
(Amyloidosis...) :
Studies in vitro and in vivo demonstrated that the expression of
SAA genes is
regulated by the inflammatory cytokine
interleukin-1 ... Moreover, both the
interleukin-1 induced expression and the enhanced liver-specific expression of the
SAA gene are controlled by the binding of nuclear proteins to specific DNA sequences upstream from the structural gene
Bozinovski et al., Proc Natl Acad Sci U S A 2012
(Pneumonia...) :
Immunohistochemistry detected SAA was in close proximity to airway epithelium, and in vitro
SAA triggered release of
IL-8 and other proinflammatory mediators by airway epithelial cells in an ALX/FPR2 ( formyl peptide receptor 2 ) receptor dependent manner
Mackiewicz et al., Biochem J 1988
:
Comparison of these findings with those in human hepatoma cell lines, in which
interleukin-1 does not
induce serum amyloid A synthesis, suggests that the effect of interleukin-1 on serum amyloid A synthesis may be indirect
Weinstein et al., J Trauma 1987
(Acute-Phase Reaction...) :
The
effect of
interleukin-1 on mouse liver
serum amyloid A mRNA levels was investigated
Moshage et al., Biochem Biophys Res Commun 1988
:
The
effect of
interleukin-1 , interleukin-6 and its interrelationship on the synthesis of
serum amyloid A and C-reactive protein in primary cultures of adult human hepatocytes