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FOXO1 — MLST8

Text-mined interactions from Literome

Partovian et al., Mol Cell 2008 : Reduced mTORC2 activity in S4 ( -/- ) endothelial cells results in decreased FoxO1/3a and eNOS phosphorylation, decreased endothelial cell size, and increased arterial blood pressure in S4 ( -/- ) mice
Chen et al., Dev Cell 2010 : Activated FoxO1 inhibits mTORC1 by TSC2 dependent and TSC2 independent mechanisms ... Thus, under stress conditions, FoxO inhibits the anabolic activity of mTORC1 , a major consumer of cellular energy, while activating Akt, which increases cellular energy metabolism, thereby maintaining cellular energy homeostasis
Rao et al., Immunity 2012 : The Foxo1 inactivation was dependent on mTORC1 kinase, given that blockade of mTORC1 abrogated mTORC2 mediated Akt ( Ser473 ) kinase phosphorylation, resulting in Foxo1 dependent switch from T-bet to Eomesodermin transcription factor activation and increase in memory precursors
Melnik et al., Exp Dermatol 2013 : This hypothesis postulates that antiacne agents either enhance nuclear FoxO activity or inhibit mTORC1