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IRF6 — PRKAB2

Text-mined interactions from Literome

Shang et al., Hepatology 2009 (Acute Lung Injury...) : Importantly, we show that inhibition of UCP2 activity by its pharmacological inhibitor genipin prevents LPS/GalN induced ATP reduction, AMPK activation , and apoptosis
Ceylan-Isik et al., J Mol Cell Cardiol 2010 (Inflammation...) : LPS activated AMPK and its downstream signaling ACC in conjunction with an elevated AMP/ATP ratio, which was unaffected by MT. Taken together, our data favor a beneficial effect of MT in the management of cardiac dysfunction in sepsis
Yang et al., J Biol Chem 2010 (Insulin Resistance...) : Activating AMPK signaling in macrophages by 5-aminoimidazole-4-carboxamide-1-beta4-ribofuranoside or constitutively active alpha1AMPK ( CA-alpha1 ) significantly inhibits ; although inhibiting alpha1AMPK by short hairpin RNA knock-down or dominant negative alpha1AMPK ( DN-alpha1 ) increases LPS- and FFA induced tumor necrosis factor alpha expression ... Chromatin immunoprecipitation and luciferase reporter assays show that activation of AMPK by CA-alpha1 in macrophages significantly inhibits LPS- or FFA induced NF-kappaB signaling