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IRF6 — PLAUR
Text-mined interactions from Literome
Ogura et al., J Periodontol 1999
(Periodontal Diseases) :
LPS increased the protein and mRNA levels of both uPA and
uPAR in gingival fibroblasts
Bhandary et al., Am J Respir Crit Care Med 2009
(Acute Lung Injury...) :
The present study shows that
LPS induces
uPAR expression both in vitro and in vivo, and that the mechanism involves post-transcriptional stabilization of uPAR mRNA by reciprocal interaction of phosphoglycerate kinase ( PGK ) and heterogeneous nuclear ribonucleoprotein C ( hnRNPC ) with uPAR mRNA coding region and 3 ' untranslated region determinants, respectively ... Our study shows that induction of
LPS mediated
uPAR expression is mediated through tyrosine phosphorylation of PGK and hnRNPC
Killeen et al., Br J Cancer 2009
(Carcinoma...) :
LPS upregulates u-PA and
u-PAR in a dose dependent manner, enhancing in vitro tumour cell vitronectin adhesion and ECM invasion by > 40 % ( P < 0.01 )
Baldi et al., Res Vet Sci 2012
:
This study examined the
effects of Escherichia coli
lipopolysaccharide (LPS) on cell viability, the modulation of cell associated u-PA activity, and the regulation of u-PA and
u-PA receptor (u-PAR) RNA expression using the BME-UV1 bovine mammary epithelial cell line ... These data indicated that E. coli
LPS led to an increase in u-PA activity and RNA expression of u-PA and
u-PAR in BME-UV1 cells, thus strengthening the role of the PA system during pathological processes