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HDAC1 — NOTCH1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Notch-mediated HES/HEY network: RBPJ/NCoR/HDAC1 complex (RBPJ-NCOR1_NCOR2-HDAC1) → RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300) (modification, collaborate)
  Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Notch-mediated HES/HEY network: RBPJ/NCoR/HDAC1 complex (RBPJ-NCOR1_NCOR2-HDAC1) → NICD (NOTCH1) (modification, collaborate) Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Notch-mediated HES/HEY network: RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300) → HDAC1 (HDAC1) (modification, collaborate) Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Notch-mediated HES/HEY network: HDAC1 (HDAC1) → NICD (NOTCH1) (modification, collaborate) Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Notch-mediated HES/HEY network: RBPJ/NCoR/HDAC1 complex (RBPJ-NCOR1_NCOR2-HDAC1) → RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300) (transcription, inhibits)
  Ohtsuka et al., EMBO J 1999, Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Jarriault et al., Nature 1995, Nishimura et al., Genomics 1998, Kao et al., Genes Dev 1998
  Evidence: mutant phenotype, reporter gene
• NCI Pathway Database Notch signaling pathway: RBPJ/NCoR/HDAC1 complex (RBPJ-NCOR1_NCOR2-HDAC1) → RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2) (modification, collaborate)
  Wu et al., Nat Genet 2000, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Notch signaling pathway: RBPJ/NCoR/HDAC1 complex (RBPJ-NCOR1_NCOR2-HDAC1) → NICD (NOTCH1) (modification, collaborate) Wu et al., Nat Genet 2000, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Notch signaling pathway: RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2) → HDAC1 (HDAC1) (modification, collaborate) Wu et al., Nat Genet 2000, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Notch signaling pathway: HDAC1 (HDAC1) → NICD (NOTCH1) (modification, collaborate) Wu et al., Nat Genet 2000, Wu et al., Mol Cell Biol 2002, Tamura et al., Curr Biol 1995, Kao et al., Genes Dev 1998
  Evidence: mutant phenotype, assay, physical interaction
• Reactome Reaction: HDAC1 → NOTCH1 (reaction) Zhou et al., Mol Cell Biol 2000, Perissi et al., Cell 2004, Perissi et al., Mol Cell 2008, Oka et al., Development 1995, Kao et al., Genes Dev 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: HDAC1 — NOTCH1 (physical association, affinity chromatography technology) Yatim et al., Mol Cell 2012

Text-mined interactions from Literome

Chen et al., Basic Clin Pharmacol Toxicol 2007 (Leukemia) : Curcumin, both histone deacetylase and p300/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells
Xiao et al., Mol Cancer Ther 2009 (Adenocarcinoma, Follicular...) : We have previously shown that Notch1 may function as a tumor suppressor and that histone deacetylase (HDAC) inhibitors can induce Notch1 expression in some endocrine cancers ... These results indicate that HDAC inhibitors activate Notch1 signaling in thyroid cancer cells and lead to the suppression of proliferation by cell cycle arrest
Cayo et al., American journal of translational research 2009 : We hypothesized that the HDAC inhibitor Sodium Butyrate ( NaB ) might activate Notch1 in pheochromocytoma resulting in altered tumor cell proliferation
Hughes et al., Cancer Treat Res 2009 (Bone Neoplasms...) : Further, exposure to valproic acid at therapeutic concentrations induced expression of Notch genes and caused a 250-fold increase in invasiveness for non-invasive cell lines, but had no discernible effect on those lines that expressed high levels of Notch without valproic acid treatment, suggesting a role for HDAC in regulating Notch pathway expression in osteosarcoma
Mulligan et al., Mol Cell 2011 : A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development
Tseng et al., PloS one 2011 : Inhibition of HDAC function resulted in aberrant expression of Notch1 and BMP2, two genes known to be required for tail regeneration
Tang et al., Journal of the American Heart Association 2012 : However, inhibition of HDAC activity did not suppress Notch activation of the HRT target genes ... Although CBF-1 mediated Notch signaling was increased by HDAC inhibition in human SMCs and in a C3H10T1/2 model, SMC differentiation was inhibited in both cases ... Although CBF-1 mediated Notch signaling is not suppressed by HDAC inhibition, HDAC activity is required for Notch differentiation signals through mitogen activated protein kinase and PI3K pathways in SMCs. ( J Am Heart Assoc. 2012 ; 1 : e000901 doi : 10.1161/JAHA.112.000901 )
Zhao et al., Neoplasia (New York, N.Y.) 2013 : We showed that hD1R could bind to ECs specifically through its RGD motif and effectively triggered Notch signaling in ECs