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GCG — MAPK1
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Li et al., Hypertension 2006
(Calcium Signaling) :
Total
ERK 1/2 was not
affected by
glucagon ... Pretreating of mesangial cells with U73122 or H89 significantly attenuated
ERK 1/2 phosphorylation
induced by
glucagon
Li et al., Biochem Pharmacol 2006
:
We have recently shown that the pancreatic hormone
glucagon induced phosphorylation of mitogen activated protein ( MAP ) kinase
ERK 1/2 as well as growth and proliferation of rat glomerular mesangial cells (MCs) via activation of cAMP dependent protein kinase A (PKA)- and phospholipase C (PLC)/Ca2+ mediated signaling pathways ... Since circulating glucagon and tissue angiotensin II (Ang II) levels are inappropriately elevated in type 2 diabetes, we tested the hypothesis that
glucagon induces phosphorylation of
ERK 1/2 in MCs by interacting with Ang II receptor signaling ... Inhibition of cAMP dependent PKA with H89 ( 1 microM ) or PLC with U73122 ( 1 microM ) also markedly attenuated the phosphorylation of
ERK 1/2 induced by
glucagon ( glucagon + U73122 : 109+/-15 % ; glucagon + H89 : 113+/-16 % ; p < 0.01 versus glucagon ) or Ang II ( Ang II + U73122 : 111+/-13 % ; Ang II + H89 : 86+/-10 % ; p < 0.01 versus Ang II ) ... These results suggest that AT1 receptor activated cAMP dependent PKA, PLC and PI 3-kinase signaling is involved in
glucagon induced MAP kinase
ERK 1/2 phosphorylation in MCs ... The inhibitory effect of PD 123319 on
glucagon induced
ERK 1/2 phosphorylation further suggests that AT2 receptors also play a similar role in this response
Reimer et al., J Endocrinol 2006
:
Meat hydrolysate and essential amino acid induced
glucagon-like peptide-1 secretion, in the human NCI-H716 enteroendocrine cell line, is
regulated by
extracellular signal regulated kinase1/2 and p38 mitogen activated protein kinases
Ulrich et al., Cell Biochem Funct 1998
:
Activation and
glucagon regulation of mitogen activated protein kinases (
MAPK ) by insulin and epidermal growth factor in cultured rat and human hepatocytes ...
Glucagon also
reduced the activation of
MAPK by EGF in rat hepatocytes