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CDC34 — CUL1

Pathways - manually collected, often from reviews:

• BioCarta e2f1 destruction pathway: E2F-1 (E2F1) → SKP2/SKP1/CUL1/CDC34 complex (SKP2-SKP1A-CUL1-CDC34) (protein ubiquitination, collaborate)
  
• BioCarta cyclin e destruction pathway: FBW7/SKP1/CUL1/CDC34 complex (FBXW7-SKP1A-CUL1-CDC34) → Cyclin E (CCNE1) (protein ubiquitination, activates)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CUL1 — CDC34 (direct interaction, enzymatic study) Morimoto et al., Biochem Biophys Res Commun 2003*
• IRef Biogrid Interaction: CUL1 — CDC34 (direct interaction, fluorescent resonance energy transfer) Saha et al., Mol Cell 2008*
• IRef Biogrid Interaction: CUL1 — CDC34 (direct interaction, pull down) Ohta et al., Cancer Res 2001*
• IRef Biogrid Interaction: CUL1 — CDC34 (direct interaction, pull down) Block et al., Cell cycle (Georgetown, Tex.) 2005*
• IRef Biogrid Interaction: CUL1 — CDC34 (direct interaction, pull down) Wirbelauer et al., EMBO J 2000*
• MIPS CORUM Ubiquitin E3 ligase (CDC34, CUL1, RBX1): Ubiquitin E3 ligase (CDC34, CUL1, RBX1) complex (CDC34-CUL1-RBX1) Wu et al., J Biol Chem 2002*
• IRef Hprd Interaction: CUL1 — CDC34 (in vitro) Block et al., Cell cycle (Georgetown, Tex.) 2005*
• IRef Hprd Interaction: Complex of 37 proteins (in vivo) Read et al., Mol Cell Biol 2000
• IRef Hprd Interaction: Complex of 13 proteins (in vivo) Wu et al., J Biol Chem 2002*
• IRef Intact Interaction: CUL1 — CDC34 (direct interaction, cross-linking study) Kleiger et al., Cell 2009*
• IRef Intact Interaction: Complex of 24 proteins (physical association, anti tag coimmunoprecipitation) Sowa et al., Cell 2009
• IRef Intact Interaction: Complex of CUL1-CDC34 (physical association, fluorescent resonance energy transfer) Kleiger et al., Cell 2009*
• IRef Intact Interaction: Complex of CUL1-CDC34-BTRC-SKP1 (physical association, fluorescent resonance energy transfer) Kleiger et al., Cell 2009*