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Tan et al., J Biol Chem 2002
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Overexpression of ILK stimulated NF-kappaB activity and inhibition of ILK or protein kinase B ( PKB/Akt ) suppressed this activation
Makino et al., Oncogene 2004
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Here, we show that integrin linked kinase (ILK) , the crucial signal transducer in the integrin pathway, is involved in HER2/neu mediated activation of NF-kappaB Medici et al., Matrix Biol 2010
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Type I collagen promotes epithelial-mesenchymal transition through ILK dependent activation of NF-kappaB and LEF-1 ... Here we show that collagen I causes ILK dependent phosphorylation of IkappaB and subsequent nuclear translocation of active NF-kappaB , which in turn promotes increased expression of the Snail and LEF-1 transcription factors