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MAP3K1 — MAPK11
Pathways - manually collected, often from reviews:
-
KEGG RIG-I-like receptor signaling pathway:
MAP3K1
→
MAPK11/MAPK12/MAPK13/MAPK14
(protein-protein, activation)
-
NCI Pathway Database CD40/CD40L signaling:
CD40/CD40L (trimer)/TRAF2 (trimer)/MEKK1 complex (CD40LG-CD40-TRAF2-MAP3K1)
→
p38alpha-beta-active (MAPK14/MAPK11)
(modification, activates)
Haxhinasto et al., J Immunol 2002, Jabara et al., Immunity 2002, Gallagher et al., Nat Immunol 2007
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database CD40/CD40L signaling:
CD40/CD40L (trimer)/TRAF2 (trimer)/MEKK1 complex (CD40LG-CD40-TRAF2-MAP3K1)
→
p38alpha-beta (MAPK14/MAPK11)
(modification, activates)
Haxhinasto et al., J Immunol 2002, Jabara et al., Immunity 2002, Gallagher et al., Nat Immunol 2007
Evidence: mutant phenotype, assay, physical interaction
Text-mined interactions from Literome
Uhlik et al., Biochem Cell Biol 2004
(MAP Kinase Signaling System) :
Wiring diagrams of
MAPK regulation by
MEKK1 , 2, and 3
Korchnak et al., Cell Signal 2009
:
Mixed lineage kinase 3 (MLK3) is a mitogen activated protein kinase kinase kinase (
MAP3K ) that
activates multiple mitogen activated protein kinase (
MAPK ) pathways in response to growth factors, stresses and the pro-inflammatory cytokine, tumor necrosis factor (TNF)
Xu et al., Proc Natl Acad Sci U S A 1995
:
MEKK1 phosphorylates MEK1 and MEK2 but does not
cause activation of
mitogen activated protein kinase