◀ Back to CD40
CD40 — TRAF1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database CD40/CD40L signaling:
CD40/CD40L (trimer)/TTRAP complex (CD40LG-CD40-TDP2)
→
CD40/CD40L (trimer)/TRAF2 (trimer)/TRAF1 complex (CD40LG-CD40-TRAF2-TRAF1)
(modification, inhibits)
Pullen et al., J Biol Chem 1999, Pype et al., J Biol Chem 2000, Hostager et al., J Biol Chem 2003, Xie et al., J Immunol 2006
Evidence: mutant phenotype, assay
-
NCI Pathway Database CD40/CD40L signaling:
TRAF2/CBL-b complex (TRAF2-CBLB)
→
CD40/CD40L (trimer)/TRAF2 (trimer)/TRAF1 complex (CD40LG-CD40-TRAF2-TRAF1)
(proteasomal ubiquitin-dependent protein catabolic process, collaborate)
Brown et al., J Exp Med 2001, Brown et al., J Biol Chem 2002, Arron et al., J Exp Med 2002, Qiao et al., J Immunol 2007
Evidence: mutant phenotype, assay
-
NCI Pathway Database CD40/CD40L signaling:
TRAF1 (TRAF1)
→
CD40/CD40L (trimer)/TRAF2 (trimer) complex (CD40LG-CD40-TRAF2)
(modification, collaborate)
Rothe et al., Science 1995
Evidence: physical interaction
-
NCI Pathway Database CD40/CD40L signaling:
TRAF1 (TRAF1)
→
CD40/CD40L (trimer)/TRAF2 (trimer)/TRAF1 complex (CD40LG-CD40-TRAF2-TRAF1)
(modification, collaborate)
Rothe et al., Science 1995
Evidence: physical interaction
-
NCI Pathway Database CD40/CD40L signaling:
CD40/CD40L (trimer)/TRAF2 (trimer) complex (CD40LG-CD40-TRAF2)
→
CD40/CD40L (trimer)/TRAF2 (trimer)/TRAF1 complex (CD40LG-CD40-TRAF2-TRAF1)
(modification, collaborate)
Rothe et al., Science 1995
Evidence: physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
TRAF1
—
CD40
(physical association, affinity chromatography technology)
Pullen et al., Biochemistry 1998
-
IRef Hprd Interaction:
TRAF1
—
CD40
(in vitro)
McWhirter et al., Proc Natl Acad Sci U S A 1999*, Hu et al., J Biol Chem 1994*
-
IRef Hprd Interaction:
TRAF1
—
CD40
(in vivo)
McWhirter et al., Proc Natl Acad Sci U S A 1999*, Hu et al., J Biol Chem 1994*
-
MIPS Negatome - no physical interaction between proteins Interaction:
TRAF1
—
CD40
(Absence of interaction, affinity chromatography technologies)
Leo et al., J Biol Chem 1999*
-
IRef Ophid Interaction:
TRAF1
—
CD40
(aggregation, confirmational text mining)
Hu et al., J Biol Chem 1994*
-
IRef Ophid Interaction:
TRAF1
—
CD40
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Pullen et al., J Biol Chem 1999
:
These studies suggest a
role in
CD40 signaling for competitive
TRAF binding and imply that CD40 responses reflect an integration of signals from individual TRAFs
Leo et al., J Biol Chem 1999
:
In contrast,
TRAF6 ( DeltaN ) did not
impair JNK activation by
CD40 ( Delta32 )
Webster-Cyriaque et al., J Virol 2000
(AIDS-Related Opportunistic Infections...) :
Effects
induced by activated
TRAF signaling that were detected in HLP included activation of NF-kappaB and c-Jun terminal kinase 1 (JNK1) and upregulated expression of epidermal growth factor receptor (EGFR),
CD40 , A20, and TRAFs
Pearson et al., Int Immunol 2001
(Leukemia, Monocytic, Acute...) :
In THP1 cells,
CD40 ligation
induced expression of
TRAF1 and TRAF5 mRNAs
Dunn et al., Mol Immunol 2000
:
We have shown that
CD40 engagement
induces TRAF1 gene expression in B lymphocytes ... Here we report that
CD40 dependent
TRAF1 gene transcription in murine B cells is controlled by two enhancer regions
Hostager et al., J Immunol 2002
:
Furthermore, although both CD40 and CD120b can bind TRAF2,
TRAF2 dependent
CD40 signals can not substitute for TRAF2 dependent CD120b signals in the activation of IgM secretion
Li et al., American journal of physiology. Renal physiology 2002
:
CD40 ligation
stimulates MCP-1 and IL-8 production,
TRAF6 recruitment, and MAPK activation in proximal tubule cells
Chan et al., Biochem Biophys Res Commun 2005
:
TRAF dependent association of protein kinase Tpl2/COT1 ( MAP3K8 ) with
CD40
Graham et al., J Immunol 2009
:
LMP1 does n't
induce TRAF degradation, and employs TRAF3 as a positive mediator of cell signaling, whereas
CD40 signals are inhibited by TRAF3