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F2R — RHOA
Text-mined interactions from Literome
Greenberg et al., Biochemistry 2003
:
Stimulation with 150 microM PAR activating peptides TFFLRN ( PAR1 ), SLIGKV ( PAR2 ), and AYPGKF ( PAR4 ) demonstrated that
PAR1 and PAR2
mediated protease activated
RhoA signaling
Jenkins et al., J Clin Invest 2006
(Pulmonary Edema...) :
This effect is
PAR1 specific and is
mediated by
RhoA and Rho kinase
Huang et al., J Biol Chem 2007
(Calcium Signaling) :
Subsequent experiments revealed that Myr-G ( 13 ) SRI ( pep ) specifically bound to platelet RhoA guanine nucleotide exchange factor ( p115RhoGEF ) and blocked
PAR1 mediated
RhoA activation in platelets and human embryonic kidney cells
Loberg et al., J Cell Biochem 2007
(Prostatic Neoplasms) :
PAR1 mediated
RhoA activation facilitates CCL2 induced chemotaxis in PC-3 cells
Tauseef et al., Circ Res 2008
(Pulmonary Edema) :
In SPHK1 depleted cells,
PAR-1 activation failed to induce Rac1 activation but
augmented RhoA activation and endothelial hyperpermeability response
Soh et al., Proc Natl Acad Sci U S A 2011
:
Activation of
PAR1 by the coagulant protease thrombin
results in
Ras homolog gene family member A (RhoA) activation, disassembly of adherens junctions, and disruption of the endothelial barrier