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CXCR4 — ITGB1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of FN1-ITGA5-ITGB1 → CXCR4 (increases, FN1/ITGA5/ITGB1 Activity) Robledo et al., J Biol Chem 2001*
  Evidence: Furthermore, the chemokine SDF-1alpha, the ligand of CXCR4, triggered modulation of beta(1) integrin-dependent melanoma cell adhesion to fibronectin.

Text-mined interactions from Literome

Grzesiak et al., Surgery 2007 (Pancreatic Neoplasms) : Growth studies showed further that CXCR4 expression on Ln-1 was mediated by the alpha(6)beta(1) integrin whereas IL-8 expression was mediated by both the alpha ( 6 ) beta ( 1 ) and alpha ( 3 ) beta ( 1 ) integrins
Jiang et al., Chin Med J (Engl) 2007 (Neoplasm Invasiveness...) : CXCL12 and its receptor CXCR4 can promote the proliferation, migration, invasion of ovarian cancer cell line CAOV-3 and enhance its secretion of integrin beta(1) and VEGF-C