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CXCR4 — IL10

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CXCR4 → IL10 (decreases, IL10 Translocation) Wang et al., J Biol Chem 2001*
  Evidence: and up-regulated by IL-10 and transforming growth factor-beta 1. Down-regulation was mediated post-translationally, in the absence of protein degradation, through an endocytotic mechanism.

Text-mined interactions from Literome

Jinquan et al., Immunology 2000 (Inflammation) : The regulation of CXCR4 expression in CD4+ T lymphocytes by IL-4 and IL-10 could be blocked by a selective inhibitor of protein kinase ( staurosporine ) or by a selective inhibitor of cAMP- and cGMP dependent protein kinase ( H-8 ), indicating that these cytokines regulate CXCR4 on CD4+ T lymphocytes via both cAMP and cGMP signalling pathways
Wilson et al., Infect Immun 1995 (Leishmaniasis, Visceral) : Recombinant Lcr1 , cloned adjacent to polyhistidine and purified on a nickel affinity column, stimulated gamma interferon but not interleukin-4 (IL-4), IL-5, or IL-10 secretion by T-cell enriched splenocytes from either susceptible or resistant mice during L. chagasi infection