Park et al., Biochem Biophys Res Commun 2007
(Embryo Loss) :
TRIP also directly interacts with the familial cylindromatosis tumor suppressor gene ( CYLD ) and negatively regulates NF-kappaB activation in vitro
Lee et al., J Exp Med 1997
:
When associated, TRIP inhibits the TRAF2 mediated NF-kappaB activation that is required for cell activation and also for protection against apoptosis