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CPOX — TNF

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Chen et al., J Immunol 2000 : TNF-alpha induced a dose- and time dependent increase in cyclooxygenase-2 (COX-2) expression and PGE2 formation in human NCI-H292 epithelial cells
Chen et al., Mol Pharmacol 2001 : The role of p44/42 mitogen activated protein kinase ( MAPK ), p38, and c-Jun NH ( 2 ) -terminal kinase ( JNK ) in tumor necrosis factor (TNF)-alpha induced cyclooxygenase (COX)-2 expression was studied in NCI-H292 epithelial cells
Weaver et al., Gastroenterology 2001 : In HT-29 and Caco-2 colonic epithelial cells, COX-2 expression was induced by either TNF-alpha or interleukin (IL)-1alpha as observed by Northern and Western analyses
Subbarayan et al., Cancer Res 2001 (Prostatic Neoplasms) : Although it is low in stromal and tumor cells, COX-2 expression is induced by TNF-alpha in these cells, and this responsiveness may play an important role in prostate cancer progression
Kaltschmidt et al., BMC molecular biology 2002 : In the murine neuroblastoma cell line NB-4, which is characterized by constitutive NF-kappaB activity, COX-2 promoter activity could not be further increased with PMA or TNF
Nakata et al., Cancer Sci 2003 (Disease Progression...) : Inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1beta stimulated the expression of G-CSF, GM-CSF, and cyclooxygenase (COX)-2 in the two cell lines
Kast et al., Mol Immunol 2003 (Neoplasms) : Since cyclooxygenase, COX, is the rate controlling enzyme in PGE production, COX inhibitors, otherwise known as non-steroidal anti-inflammatory drugs ( NSAID ), increase TNF synthesis and release by depriving AC of PGE ... This paper reviews the data on TNF up-regulation by tenofovir and COX inhibitors and the consequent augmented antigen driven lymphocyte proliferation secondary to increased TNF and suggests exploration of tenofovir and COX inhibitors like indomethacin, diclofenac or ketorolac in augmentation of current cancer immunotherapy attempts
Tanigawa et al., Am J Physiol Gastrointest Liver Physiol 2004 (Gastritis...) : Effects of COX inhibitors on neutrophil infiltration, apoptosis, and TNF-alpha expression in H. pylori infected mice were abolished by exogenous 16,16-dimethyl PGE2
Okuda et al., Biol Reprod 2004 : When cultured bovine stromal cells were exposed to TNFalpha ( 0.006-0.6 nM ) for 24 h, the production of PGF2alpha and cyclooxygenase (COX)-2 gene expression were stimulated by TNFalpha ( 0.06-0.6 nM, P < 0.05 )
Premyslova et al., J Clin Endocrinol Metab 2003 (Bacterial Infections...) : We have evaluated the effect of chorioamnionitis on the protein expression of microsomal and cytosolic prostaglandin E ( 2 ) synthases ( mPGES and cPGES ) in preterm human placentae ( PL ) and fetal membranes ( FM ), by Western blot and immunohistochemistry, as well as the regulatory effect of IL-1beta and TNF-alpha on mPGES, cPGES, and cyclooxygenase (COX)-2 expression in villous trophoblast ( VT ) and chorion trophoblast ( CT ) cell cultures
Cavin et al., Biochem Biophys Res Commun 2005 : Two independent mechanisms of action were identified : ( 1 ) a drastic inhibition of the induction by TNF-alpha of cyclooxygenase 2 (COX-2) protein expression and ( 2 ) a direct inhibition of COX enzyme activities with a significantly higher selectivity for COX-2 activity
Stebulis et al., J Rheumatol 2005 (Arthritis...) : Tumor necrosis factor-alpha (TNF-alpha) induced interleukin 6 (IL-6), IL-8, and cyclooxygenase 2 (COX-2) mRNA levels were assessed
Ackerman et al., Biol Reprod 2005 : We observed that COX2 expression and PGE2 production induced by tumor necrosis factor alpha (TNF) were significantly abrogated by 15d-PGJ2
Li et al., J Infect Dis 2006 (Disease Models, Animal...) : Tumor necrosis factor (TNF)-alpha and interleukin-10 mRNA expression was elevated in H. pylori infected mice, but only TNF-alpha mRNA expression was further increased by COX deficiency
Yan et al., J Cell Sci 2006 (Cell Transformation, Neoplastic) : NFAT3 is specifically required for TNF-alpha induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells
Nishimura et al., Biosci Biotechnol Biochem 2006 : TNF-alpha preferentially promoted gene expression of cyclooxygenase (COX)-2 without affecting that of COX-1
Ahn et al., Cancer Res 2007 (Skin Neoplasms) : The induction of various antiapoptotic gene products ( MMP-9, cyclin D1, COX-2 , IAP1, IAP2, Bcl-2, cFLIP, and XIAP ) by TNF was also abolished in NQO2-/- cells
Lee et al., J Immunol 2008 : Specifically in response to TNF-alpha , TGF-beta, and LPS, protein expression of cyclooxygenase (COX)-2 and downstream PGE synthase was up-regulated with coordinate kinetics, whereas COX-1 and PGIS were constitutively expressed
Barakat et al., Naunyn Schmiedebergs Arch Pharmacol 2009 (Brain Ischemia...) : Furthermore, OGD and the NF-kappaB activator tumor necrosis factor stimulated the expression of cPLA-2, cyclooxygenase-2 (COX-2) , and mPGES-1 and increased the release of PGE ( 2 ) from neurons
Trefiletti et al., Br J Nutr 2011 (Inflammation) : The results showed that L137 significantly inhibited both prostanoid and TNF-a production in lipopolysaccharide primed human monocytes in a dose dependent manner, by inhibiting the COX activity of COX-2
Nishanth et al., Nanotoxicology 2011 : A significant increase in IL-6, reactive oxygen species ( ROS ) generation, nuclear translocation of nuclear factor-kappa B ( NF-?B ), induction of cyclooxygenase-2 (COX-2) , and tumor necrosis factor-alpha ( TNF-a ) expression was observed in macrophages with maximum response found in cells exposed to Ag NPs followed by Al, CB and CAg
Kim et al., J Pharmacol Exp Ther 2011 : Targeting tumor necrosis factor (TNF)-a mediated signal pathways may be a promising strategy for developing chemopreventive agents, because TNF-a mediated cyclooxygenase (COX)-2 expression plays a key role in inflammation and carcinogenesis
Battula et al., Prostaglandins Other Lipid Mediat 2012 (Hypercalcemia...) : The effect of tumor necrosis factor-alpha (TNF) on cyclooxygenase-2 (COX-2) expression in the renal outer medulla ( OM ) was determined in a model of dihydrotachysterol ( DHT ) -induced hypercalcemia
Thakur et al., Journal of translational medicine 2013 (Pancreatic Neoplasms) : Reduced accumulation of MDSC was accompanied by significantly lower levels of COX2 ( p < 0.0048 ), PGE2 ( p < 0.03 ), and their downstream effector molecule Arginase-1 ( p < 0.01 ), and significantly higher levels of TNF-a , IL-12 and chemokines CCL3, CCL4, CCL5, CXCL9 and CXCL10 under aATC induced Th1 cytokine enriched microenvironment
Li et al., Fertil Steril 2013 (Adenomyosis) : To investigate the action of nuclear factor ( NF ) -?B in adenomyosis and evaluate the potential therapeutic effect of andrographolide on tumor necrosis factor (TNF)-a induced expression of NF-?B mediated genes cyclooxygease-2 (COX-2) , vascular endothelial growth factor ( VEGF ), and tissue factor ( TF ) in adenomyotic stromal cells
Song et al., Journal of ginseng research 2012 : Air dried PG leaf extract inhibited TNF-a induced NF-?B transcription activity and NF-?B dependent cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) gene expression more efficiently than the steamed extract
Akarasereenont et al., Br J Pharmacol 1995 : These results suggest that ( i ) the induction of COX activity and COX-2 protein elicited by LPS in BAEC is mediated by TNF-alpha with lesser contributions from PDGF, EGF or IL-1 beta ; ( ii ) exogenous IL-1 beta, TNF-alpha or EGF alone induce COX-2 activity and protein in BAEC ; ( iii ) PDGF synergizes with IL-1 beta, but not TNF-alpha, to cause expression of COX-2 ; and ( iv ) the induction of COX-2 protein and activity caused by these cytokines involves the activation of tyrosine kinase
Pang et al., Br J Pharmacol 1997 : 2. We studied the effects of IL-1 beta, TNF alpha and IFN gamma on the induction of two isoforms of cyclo-oxygenase and its relation to prostaglandin E2 ( PGE2 ) release and COX activity ( reflected by PGE2 synthesis from exogenous arachidonic acid ) in human cultured airway smooth muscle cells
Fournier et al., J Biol Chem 1997 : Neither COX1 nor COX2 protein levels were affected by TNFalpha or PKA activators used alone, whereas in association, marked up-regulation of COX2 mRNA and protein was observed